tetano
Editor, Senior Moderator
Acta Neurol Belg
. 2021 May 5.
doi: 10.1007/s13760-021-01693-3. Online ahead of print.
Neurological diseases and COVID-19: prospective analyses using the UK Biobank
Nicola Veronese[SUP] 1 [/SUP], Lee Smith[SUP] 2 [/SUP], Mario Barbagallo[SUP] 3 [/SUP], Gianluigi Giannelli[SUP] 4 [/SUP], Maria Gabriella Caruso[SUP] 4 [/SUP], Anna Maria Cisternino[SUP] 4 [/SUP], Maria Notarnicola[SUP] 4 [/SUP], Chao Cao[SUP] 5 6 [/SUP], Thomas Waldhoer[SUP] 7 [/SUP], Lin Yang[SUP] 8 9 [/SUP]
Affiliations
Abstract
COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ? 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00-G99). COVID-19 presence was diagnosed using the data provided by Public Health England. The association of previous diagnosis of neurological conditions with COVID-19 was evaluated through logistic regressions, adjusted for potential confounders, reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Nerve, nerve root and plexus disorders (G50-G59) were the most common conditions identified. The presence of COVID-19 was almost doubled in neurological conditions compared to the general population (0.45 vs. 0.24%, p < 0.0001). Previously diagnosed neurological conditions were associated with 60% higher odds of COVID-19 positive in the multivariable-adjusted model (OR = 1.6, 95% CI 1.4-1.8). Other degenerative diseases of the nervous system, extrapyramidal and movement disorders, polyneuropathies and other disorders of the peripheral nervous system, cerebral palsy and other paralytic syndromes were significantly associated with a higher odds of COVID-19. The presence of neurological conditions was associated with a significantly higher likelihood of COVID-19 compared to the general population.
Keywords: COVID-19; Neurological conditions; UK Biobank.
. 2021 May 5.
doi: 10.1007/s13760-021-01693-3. Online ahead of print.
Neurological diseases and COVID-19: prospective analyses using the UK Biobank
Nicola Veronese[SUP] 1 [/SUP], Lee Smith[SUP] 2 [/SUP], Mario Barbagallo[SUP] 3 [/SUP], Gianluigi Giannelli[SUP] 4 [/SUP], Maria Gabriella Caruso[SUP] 4 [/SUP], Anna Maria Cisternino[SUP] 4 [/SUP], Maria Notarnicola[SUP] 4 [/SUP], Chao Cao[SUP] 5 6 [/SUP], Thomas Waldhoer[SUP] 7 [/SUP], Lin Yang[SUP] 8 9 [/SUP]
Affiliations
- PMID: 33954931
- DOI: 10.1007/s13760-021-01693-3
Abstract
COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ? 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00-G99). COVID-19 presence was diagnosed using the data provided by Public Health England. The association of previous diagnosis of neurological conditions with COVID-19 was evaluated through logistic regressions, adjusted for potential confounders, reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Nerve, nerve root and plexus disorders (G50-G59) were the most common conditions identified. The presence of COVID-19 was almost doubled in neurological conditions compared to the general population (0.45 vs. 0.24%, p < 0.0001). Previously diagnosed neurological conditions were associated with 60% higher odds of COVID-19 positive in the multivariable-adjusted model (OR = 1.6, 95% CI 1.4-1.8). Other degenerative diseases of the nervous system, extrapyramidal and movement disorders, polyneuropathies and other disorders of the peripheral nervous system, cerebral palsy and other paralytic syndromes were significantly associated with a higher odds of COVID-19. The presence of neurological conditions was associated with a significantly higher likelihood of COVID-19 compared to the general population.
Keywords: COVID-19; Neurological conditions; UK Biobank.