tetano
Editor, Senior Moderator
Acta Virol
. 2021 Nov 19.
doi: 10.4149/av_2021_401. Online ahead of print.
Natural immune response and protection from SARS-CoV-2 reinfection
Katia Margiotti, Marco Fabiani, Alvaro Mesoraca, Claudio Giorlandino
Abstract
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the associated disease Coronavirus Disease 2019 (COVID-19) continues to spread throughout the world, causing millions of infections and dead. One major question in predicting the course of the COVID-19 pandemic is how well and how long the immune response protect the host from reinfection. Although more studies are needed, evidence suggests that virus-specific B cell response in people with SARS-CoV-2 infection is rapidly generated and seems to be more reliable marker of long-lasting humoral responses than serum antibodies. Here we reviewed all related major studies of immune response to SARS-CoV-2 virus to better understand the natural protection against the virus, and the risk of reinfection. The ability of our community to eradicate this virus mostly will depend on our knowledge on the immune response, critical not only for vaccine development and distribution but also for therapeutic options. Keywords.
. 2021 Nov 19.
doi: 10.4149/av_2021_401. Online ahead of print.
Natural immune response and protection from SARS-CoV-2 reinfection
Katia Margiotti, Marco Fabiani, Alvaro Mesoraca, Claudio Giorlandino
- PMID: 34796710
- DOI: 10.4149/av_2021_401
Abstract
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the associated disease Coronavirus Disease 2019 (COVID-19) continues to spread throughout the world, causing millions of infections and dead. One major question in predicting the course of the COVID-19 pandemic is how well and how long the immune response protect the host from reinfection. Although more studies are needed, evidence suggests that virus-specific B cell response in people with SARS-CoV-2 infection is rapidly generated and seems to be more reliable marker of long-lasting humoral responses than serum antibodies. Here we reviewed all related major studies of immune response to SARS-CoV-2 virus to better understand the natural protection against the virus, and the risk of reinfection. The ability of our community to eradicate this virus mostly will depend on our knowledge on the immune response, critical not only for vaccine development and distribution but also for therapeutic options. Keywords.