tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2012 Oct 31. [Epub ahead of print]
Additional diagnostic yield of adding serology to PCR in diagnosing viral acute respiratory infections in Kenyan patients >= 5 years old.
Feikin DR, Njenga MK, Bigogo G, Aura B, Gikunju S, Balish A, Katz MA, Erdman D, Breiman RF.
Source
International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-Kenya.
Abstract
The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARI) is unclear. We found acute- and convalescent-phase paired serologic testing increased the diagnostic yield beyond PCR of naso/oropharyngeal swabs for influenza virus, RSV, human metapneumovirus, adenovirus and parainfluenza viruses, by 0.4%-10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.
PMID:
23114699
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23114699
Additional diagnostic yield of adding serology to PCR in diagnosing viral acute respiratory infections in Kenyan patients >= 5 years old.
Feikin DR, Njenga MK, Bigogo G, Aura B, Gikunju S, Balish A, Katz MA, Erdman D, Breiman RF.
Source
International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-Kenya.
Abstract
The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARI) is unclear. We found acute- and convalescent-phase paired serologic testing increased the diagnostic yield beyond PCR of naso/oropharyngeal swabs for influenza virus, RSV, human metapneumovirus, adenovirus and parainfluenza viruses, by 0.4%-10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.
PMID:
23114699
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23114699