tetano
Editor, Senior Moderator
Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz225. doi: 10.1093/ofid/ofz225.
[h=1]Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET).[/h] Czaja CA[SUP]1,[/SUP][SUP]2[/SUP], Miller L[SUP]2[/SUP], Alden N[SUP]1[/SUP], Wald HL[SUP]3[/SUP], Cummings CN[SUP]4[/SUP], Rolfes MA[SUP]4[/SUP], Anderson EJ[SUP]5[/SUP], Bennett NM[SUP]6[/SUP], Billing LM[SUP]7[/SUP], Chai SJ[SUP]4,[/SUP][SUP]8[/SUP], Eckel S[SUP]9[/SUP], Mansmann R[SUP]10[/SUP], McMahon M[SUP]11[/SUP], Monroe ML[SUP]12[/SUP], Muse A[SUP]13[/SUP], Risk I[SUP]14[/SUP], Schaffner W[SUP]15[/SUP], Thomas AR[SUP]16[/SUP], Yousey-Hindes K[SUP]17[/SUP], Garg S[SUP]4[/SUP], Herlihy RK[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged ≥65 years.
[h=4]METHODS:[/h] We evaluated age-related differences in influenza-associated hospitalization rates, clinical presentation, and outcomes among 19 760 older adults with laboratory-confirmed influenza at 14 FluSurv-NET sites during the 2011-2012 through 2014-2015 influenza seasons using 10-year age groups.
[h=4]RESULTS:[/h] There were large stepwise increases in the population rates of influenza hospitalization with each 10-year increase in age. Rates ranged from 101-417, 209-1264, and 562-2651 per 100 000 persons over 4 influenza seasons in patients aged 65-74 years, 75-84 years, and ≥85 years, respectively. Hospitalization rates among adults aged 75-84 years and ≥85 years were 1.4-3.0 and 2.2-6.4 times greater, respectively, than rates for adults aged 65-74 years. Among patients hospitalized with laboratory-confirmed influenza, there were age-related differences in demographics, medical histories, and symptoms and signs at presentation. Compared to hospitalized patients aged 65-74 years, patients aged ≥85 years had higher odds of pneumonia (aOR, 1.2; 95% CI, 1.0-1.3; P = .01) and in-hospital death or transfer to hospice (aOR, 2.1; 95% CI, 1.7-2.6; P < .01).
[h=4]CONCLUSIONS:[/h] Age-related differences in the incidence and severity of influenza hospitalizations among adults aged ≥65 years can inform prevention and treatment efforts, and data should be analyzed and reported using additional age strata.
Published by Oxford University Press on behalf of Infectious Diseases Society of America 2019.
[h=4]KEYWORDS:[/h] adult; epidemiology; hospitalization; human; influenza
PMID: 31363771 PMCID: PMC6602897 [Available on 2020-06-01] DOI: 10.1093/ofid/ofz225
[h=1]Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET).[/h] Czaja CA[SUP]1,[/SUP][SUP]2[/SUP], Miller L[SUP]2[/SUP], Alden N[SUP]1[/SUP], Wald HL[SUP]3[/SUP], Cummings CN[SUP]4[/SUP], Rolfes MA[SUP]4[/SUP], Anderson EJ[SUP]5[/SUP], Bennett NM[SUP]6[/SUP], Billing LM[SUP]7[/SUP], Chai SJ[SUP]4,[/SUP][SUP]8[/SUP], Eckel S[SUP]9[/SUP], Mansmann R[SUP]10[/SUP], McMahon M[SUP]11[/SUP], Monroe ML[SUP]12[/SUP], Muse A[SUP]13[/SUP], Risk I[SUP]14[/SUP], Schaffner W[SUP]15[/SUP], Thomas AR[SUP]16[/SUP], Yousey-Hindes K[SUP]17[/SUP], Garg S[SUP]4[/SUP], Herlihy RK[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged ≥65 years.
[h=4]METHODS:[/h] We evaluated age-related differences in influenza-associated hospitalization rates, clinical presentation, and outcomes among 19 760 older adults with laboratory-confirmed influenza at 14 FluSurv-NET sites during the 2011-2012 through 2014-2015 influenza seasons using 10-year age groups.
[h=4]RESULTS:[/h] There were large stepwise increases in the population rates of influenza hospitalization with each 10-year increase in age. Rates ranged from 101-417, 209-1264, and 562-2651 per 100 000 persons over 4 influenza seasons in patients aged 65-74 years, 75-84 years, and ≥85 years, respectively. Hospitalization rates among adults aged 75-84 years and ≥85 years were 1.4-3.0 and 2.2-6.4 times greater, respectively, than rates for adults aged 65-74 years. Among patients hospitalized with laboratory-confirmed influenza, there were age-related differences in demographics, medical histories, and symptoms and signs at presentation. Compared to hospitalized patients aged 65-74 years, patients aged ≥85 years had higher odds of pneumonia (aOR, 1.2; 95% CI, 1.0-1.3; P = .01) and in-hospital death or transfer to hospice (aOR, 2.1; 95% CI, 1.7-2.6; P < .01).
[h=4]CONCLUSIONS:[/h] Age-related differences in the incidence and severity of influenza hospitalizations among adults aged ≥65 years can inform prevention and treatment efforts, and data should be analyzed and reported using additional age strata.
Published by Oxford University Press on behalf of Infectious Diseases Society of America 2019.
[h=4]KEYWORDS:[/h] adult; epidemiology; hospitalization; human; influenza
PMID: 31363771 PMCID: PMC6602897 [Available on 2020-06-01] DOI: 10.1093/ofid/ofz225