tetano
Editor, Senior Moderator
Aging (Albany NY)
. 2020 Jun 17;12.
doi: 10.18632/aging.103370. Online ahead of print.
Treatment Strategies of Hospitalized Patients With Coronavirus disease-19
Yaxiong Huang[SUP] 1 [/SUP], Chunlin Cai[SUP] 1 [/SUP], Jinglei Zang[SUP] 2 [/SUP], Jun Xie[SUP] 1 [/SUP], Dan Xu[SUP] 1 [/SUP], Fang Zheng[SUP] 1 [/SUP], Tao Zhan[SUP] 1 [/SUP], Kang Huang[SUP] 1 [/SUP], Yikai Wang[SUP] 3 [/SUP], Xiao Wang[SUP] 4 [/SUP], Zhe-Yu Hu[SUP] 5 [/SUP], Yapeng Deng[SUP] 5 [/SUP], Yuanlin Xie[SUP] 1 6 [/SUP]
Affiliations
Abstract
With the outbreak of coronavirus disease-19 (COVID-19), Changsha faced an increasing burden of treating the Wuhan migrants and their infected patients. This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020. Of 238 patients 43.7% visited Wuhan, 58.4% got in touch with Wuhan people, and 47.5% had contacted with diagnosed patients. 37.8% patients had family members infected. 190 cases had mild / general disease, and 48 cases had severe / critical disease. Compared to mild or general patients, more severe or critical patients visited Wuhan (59.6% vs 40.2%; P=0.02) and contacted with Wuhan people (74.5% vs 55.0%; P=0.02). All patients received antiviral treatment, including Lopinavir / Ritonavir (29.3%), Interferon (14.6%) and their combination (40.6%), Arbidol (6.7%), Xuebijing (7.1%) and Chloroquine phosphate (1.3%). Severe and critical patients received glucocorticoid, Gamma-globulin and oxygen inhalation. Some received mechanic ventilation support. As of 02/27, 161 patients discharged. The median length of hospital stay was 13 days. The 10-, 14-, 20- and 28-day discharge rate was 19.1%, 42.8%, 65.0% and 76.4%, respectively. No hospital-related transmission was observed.
Keywords: COVID-19; coronasvirus disease-19; epidemiological and clinical characteristics; outside Wuhan; prognosis; treatment strategies.
. 2020 Jun 17;12.
doi: 10.18632/aging.103370. Online ahead of print.
Treatment Strategies of Hospitalized Patients With Coronavirus disease-19
Yaxiong Huang[SUP] 1 [/SUP], Chunlin Cai[SUP] 1 [/SUP], Jinglei Zang[SUP] 2 [/SUP], Jun Xie[SUP] 1 [/SUP], Dan Xu[SUP] 1 [/SUP], Fang Zheng[SUP] 1 [/SUP], Tao Zhan[SUP] 1 [/SUP], Kang Huang[SUP] 1 [/SUP], Yikai Wang[SUP] 3 [/SUP], Xiao Wang[SUP] 4 [/SUP], Zhe-Yu Hu[SUP] 5 [/SUP], Yapeng Deng[SUP] 5 [/SUP], Yuanlin Xie[SUP] 1 6 [/SUP]
Affiliations
- PMID: 32554861
- DOI: 10.18632/aging.103370
Abstract
With the outbreak of coronavirus disease-19 (COVID-19), Changsha faced an increasing burden of treating the Wuhan migrants and their infected patients. This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020. Of 238 patients 43.7% visited Wuhan, 58.4% got in touch with Wuhan people, and 47.5% had contacted with diagnosed patients. 37.8% patients had family members infected. 190 cases had mild / general disease, and 48 cases had severe / critical disease. Compared to mild or general patients, more severe or critical patients visited Wuhan (59.6% vs 40.2%; P=0.02) and contacted with Wuhan people (74.5% vs 55.0%; P=0.02). All patients received antiviral treatment, including Lopinavir / Ritonavir (29.3%), Interferon (14.6%) and their combination (40.6%), Arbidol (6.7%), Xuebijing (7.1%) and Chloroquine phosphate (1.3%). Severe and critical patients received glucocorticoid, Gamma-globulin and oxygen inhalation. Some received mechanic ventilation support. As of 02/27, 161 patients discharged. The median length of hospital stay was 13 days. The 10-, 14-, 20- and 28-day discharge rate was 19.1%, 42.8%, 65.0% and 76.4%, respectively. No hospital-related transmission was observed.
Keywords: COVID-19; coronasvirus disease-19; epidemiological and clinical characteristics; outside Wuhan; prognosis; treatment strategies.