tetano
Editor, Senior Moderator
Cell Immunol. 2019 Oct 31:103998. doi: 10.1016/j.cellimm.2019.103998. [Epub ahead of print] [h=1]Aging and influenza vaccine-induced immunity.[/h]
Dugan HL[SUP]1[/SUP], Henry C[SUP]2[/SUP], Wilson PC[SUP]3[/SUP].
[h=3]Author information[/h] 1 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. 2 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA. Electronic address: carolehenry@uchicago.edu. 3 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.
[h=3]Abstract[/h] Immunosenescence is defined as the progressive deterioration of the immune system with aging. Immunosenescence stifles the generation of protective B and T cell-mediated adaptive immunity in response to various pathogens, resulting in increased disease susceptibility and severity in the elderly population. In particular, immunosenescence has major impacts on the phenotype, function, and receptor repertoire of B and T cells in the elderly, hindering protective responses induced by seasonal influenza virus vaccination. In order to overcome the detrimental impacts of immunosenescence on protective immunity to influenza viruses, we review our current understanding of the effects of aging on adaptive immune responses to influenza and discuss current and future avenues of vaccine research for eliciting more potent anti-influenza immunity in the elderly.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Aging; Antibody responses; B cells; Influenza; T cells; Vaccination
PMID: 31733824 DOI: 10.1016/j.cellimm.2019.103998
Dugan HL[SUP]1[/SUP], Henry C[SUP]2[/SUP], Wilson PC[SUP]3[/SUP].
[h=3]Author information[/h] 1 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. 2 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA. Electronic address: carolehenry@uchicago.edu. 3 University of Chicago, Department of Medicine, Section of Rheumatology, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address: wilsonp@uchicago.edu.
[h=3]Abstract[/h] Immunosenescence is defined as the progressive deterioration of the immune system with aging. Immunosenescence stifles the generation of protective B and T cell-mediated adaptive immunity in response to various pathogens, resulting in increased disease susceptibility and severity in the elderly population. In particular, immunosenescence has major impacts on the phenotype, function, and receptor repertoire of B and T cells in the elderly, hindering protective responses induced by seasonal influenza virus vaccination. In order to overcome the detrimental impacts of immunosenescence on protective immunity to influenza viruses, we review our current understanding of the effects of aging on adaptive immune responses to influenza and discuss current and future avenues of vaccine research for eliciting more potent anti-influenza immunity in the elderly.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Aging; Antibody responses; B cells; Influenza; T cells; Vaccination
PMID: 31733824 DOI: 10.1016/j.cellimm.2019.103998