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Aging Dis Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis With New Hopes?

tetano

tetano

Editor, Senior Moderator
Aging Dis


. 2020 May 9;11(3):477-479.
doi: 10.14336/AD.2020.0403. eCollection 2020 May.
Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis With New Hopes?


Sel?uk ?zt?rk[SUP] 1 [/SUP], Ayşe Eser El?in[SUP] 1 [/SUP], Yaşar Murat El?in[SUP] 1 [/SUP]



Affiliations

Abstract

Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. In the light of this study and previous reports, we make additional comments about possible therapeutic effects of MSCs in COVID-19 infection.

Keywords: COVID-19; cell transplantation; immunomodulation; mesenchymal stem cells; pneumonia.
 
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