tetano
Editor, Senior Moderator
AIDS
. 2020 Aug 7.
doi: 10.1097/QAD.0000000000002643. Online ahead of print.
Clinical characteristics, risk factors, and incidence of symptomatic COVID-19 in adults living with HIV: a single-center, prospective observational study
Alexy Inciarte[SUP] 1 [/SUP], Ana Gonzalez-Cordon[SUP] 1 [/SUP], Jhon Rojas[SUP] 1 [/SUP], Berta Torres[SUP] 1 [/SUP], Elisa de Lazzari[SUP] 1 [/SUP], Lorena de la Mora[SUP] 1 [/SUP], Maria Martinez-Rebollar[SUP] 1 [/SUP], Montserrat Laguno[SUP] 1 [/SUP], Pilar Callau[SUP] 1 [/SUP], Azucena Gonzalez-Navarro[SUP] 2 [/SUP], Lorna Leal[SUP] 1 [/SUP], Felipe Garcia[SUP] 1 [/SUP], Josep Mallolas[SUP] 1 [/SUP], Mar Mosquera[SUP] 3 [/SUP], Maria A Marcos[SUP] 3 [/SUP], Juan Ambrosioni[SUP] 1 [/SUP], Josep M Miro[SUP] 1 4 [/SUP], Esteban Martinez[SUP] 1 4 [/SUP], Jose L Blanco[SUP] 1 4 [/SUP], (on behalf the COVID-19 in HIV Investigators)
Affiliations
Abstract
Background: It is unclear how characteristics, risk factors, and incidence of coronavirus disease 2019 (COVID-19) in people living with HIV (PLWH) differ from the general population.
Methods: Prospective observational single-center cohort study of adult PLWH reporting symptoms of COVID-19. We assessed clinical characteristics, risk factors for COVID-19 diagnosis and severity, and standardized incidence rate ratio for COVID-19 cases in PLWH cohort and in Barcelona.
Results: From 1 March 2020 to 10 May 2020, 53 out of 5683 (0.9% confidence interval 0.7-1.2%) PLWH were diagnosed with COVID-19. Median age was 44 years, CD4 T cells were 618/μl and CD4/CD8 was 0.90. All but two individuals were virologically suppressed. Cough (87%) and fever (82%) were the most common symptoms. Twenty-six (49%) were admitted, six (14%) had severe disease, four (8%) required ICU admission, and two (4%) died. Several laboratory markers (lower O2 saturation and platelets, and higher leukocytes, creatinine, lactate dehydrogenase, C reactive protein, procalcitonin, and ferritin) were associated with COVID-19 severity. No HIV or antiretroviral-related factors were associated with COVID-19 diagnosis or severity. Standardized incidence rate ratios of confirmed or confirmed/probable COVID-19 in PLWH were 38% (95% confidence interval 27-52%, P < 0.0001) and 33% (95% confidence interval 21-50%, P < 0.0001), respectively relative to the general population.
Conclusion: PLWH with COVID-19 did not differ from the rest of the HIV cohort. Clinical presentation, severity rate, and mortality were not dependent on any HIV-related or antiretroviral-related factor. COVID-19 standardized incidence rate was lower in PLWH than in the general population. These findings should be confirmed in larger multicenter cohort studies.
. 2020 Aug 7.
doi: 10.1097/QAD.0000000000002643. Online ahead of print.
Clinical characteristics, risk factors, and incidence of symptomatic COVID-19 in adults living with HIV: a single-center, prospective observational study
Alexy Inciarte[SUP] 1 [/SUP], Ana Gonzalez-Cordon[SUP] 1 [/SUP], Jhon Rojas[SUP] 1 [/SUP], Berta Torres[SUP] 1 [/SUP], Elisa de Lazzari[SUP] 1 [/SUP], Lorena de la Mora[SUP] 1 [/SUP], Maria Martinez-Rebollar[SUP] 1 [/SUP], Montserrat Laguno[SUP] 1 [/SUP], Pilar Callau[SUP] 1 [/SUP], Azucena Gonzalez-Navarro[SUP] 2 [/SUP], Lorna Leal[SUP] 1 [/SUP], Felipe Garcia[SUP] 1 [/SUP], Josep Mallolas[SUP] 1 [/SUP], Mar Mosquera[SUP] 3 [/SUP], Maria A Marcos[SUP] 3 [/SUP], Juan Ambrosioni[SUP] 1 [/SUP], Josep M Miro[SUP] 1 4 [/SUP], Esteban Martinez[SUP] 1 4 [/SUP], Jose L Blanco[SUP] 1 4 [/SUP], (on behalf the COVID-19 in HIV Investigators)
Affiliations
- PMID: 32773471
- DOI: 10.1097/QAD.0000000000002643
Abstract
Background: It is unclear how characteristics, risk factors, and incidence of coronavirus disease 2019 (COVID-19) in people living with HIV (PLWH) differ from the general population.
Methods: Prospective observational single-center cohort study of adult PLWH reporting symptoms of COVID-19. We assessed clinical characteristics, risk factors for COVID-19 diagnosis and severity, and standardized incidence rate ratio for COVID-19 cases in PLWH cohort and in Barcelona.
Results: From 1 March 2020 to 10 May 2020, 53 out of 5683 (0.9% confidence interval 0.7-1.2%) PLWH were diagnosed with COVID-19. Median age was 44 years, CD4 T cells were 618/μl and CD4/CD8 was 0.90. All but two individuals were virologically suppressed. Cough (87%) and fever (82%) were the most common symptoms. Twenty-six (49%) were admitted, six (14%) had severe disease, four (8%) required ICU admission, and two (4%) died. Several laboratory markers (lower O2 saturation and platelets, and higher leukocytes, creatinine, lactate dehydrogenase, C reactive protein, procalcitonin, and ferritin) were associated with COVID-19 severity. No HIV or antiretroviral-related factors were associated with COVID-19 diagnosis or severity. Standardized incidence rate ratios of confirmed or confirmed/probable COVID-19 in PLWH were 38% (95% confidence interval 27-52%, P < 0.0001) and 33% (95% confidence interval 21-50%, P < 0.0001), respectively relative to the general population.
Conclusion: PLWH with COVID-19 did not differ from the rest of the HIV cohort. Clinical presentation, severity rate, and mortality were not dependent on any HIV-related or antiretroviral-related factor. COVID-19 standardized incidence rate was lower in PLWH than in the general population. These findings should be confirmed in larger multicenter cohort studies.