tetano
Editor, Senior Moderator
AJP Rep
. 2020 Jul;10(3):e224-e227.
doi: 10.1055/s-0040-1715176. Epub 2020 Aug 20.
Coronavirus Disease 2019 in a Premature Infant: Vertical Transmission and Antibody Response or Lack Thereof
Pedro Rivera-Hernandez[SUP] 1 [/SUP], Jayasree Nair[SUP] 1 [/SUP], Shamim Islam[SUP] 1 [/SUP], Lauren Davidson[SUP] 2 [/SUP], Arthur Chang[SUP] 1 [/SUP], Valerie Elberson[SUP] 1 [/SUP]
Affiliations
Abstract
With the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, several reports highlight its effects on pregnant women. Based on scant available data, vertical transmission is considered unlikely. We present here a preterm neonate born to a critically ill mother with SARV-CoV-2 with early evidence of infection with a positive reverse transcription polymerase chain reaction on day 1. Lack of parental contact prior to testing and strict adherence to recommended airborne precautions perinatally suggest vertical transmission of infection. Critical maternal illness and medications may have contributed to the need for extensive resuscitation at birth and highlight the importance of close fetal monitoring. Infant lacked immunoglobulin G antibody response by 3 weeks, presumably secondary to mild clinical course and prematurity. Effects of SARS-CoV-2 in preterm infants, their antibody response and potential for asymptomatic carriage remain uncertain.
Keywords: antibody response; coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2 in preterm; vertical transmission.
. 2020 Jul;10(3):e224-e227.
doi: 10.1055/s-0040-1715176. Epub 2020 Aug 20.
Coronavirus Disease 2019 in a Premature Infant: Vertical Transmission and Antibody Response or Lack Thereof
Pedro Rivera-Hernandez[SUP] 1 [/SUP], Jayasree Nair[SUP] 1 [/SUP], Shamim Islam[SUP] 1 [/SUP], Lauren Davidson[SUP] 2 [/SUP], Arthur Chang[SUP] 1 [/SUP], Valerie Elberson[SUP] 1 [/SUP]
Affiliations
- PMID: 33094009
- PMCID: PMC7571559
- DOI: 10.1055/s-0040-1715176
Abstract
With the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, several reports highlight its effects on pregnant women. Based on scant available data, vertical transmission is considered unlikely. We present here a preterm neonate born to a critically ill mother with SARV-CoV-2 with early evidence of infection with a positive reverse transcription polymerase chain reaction on day 1. Lack of parental contact prior to testing and strict adherence to recommended airborne precautions perinatally suggest vertical transmission of infection. Critical maternal illness and medications may have contributed to the need for extensive resuscitation at birth and highlight the importance of close fetal monitoring. Infant lacked immunoglobulin G antibody response by 3 weeks, presumably secondary to mild clinical course and prematurity. Effects of SARS-CoV-2 in preterm infants, their antibody response and potential for asymptomatic carriage remain uncertain.
Keywords: antibody response; coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2 in preterm; vertical transmission.