tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2014 Apr 21. [Epub ahead of print]
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.
Denisova OV1, S?derholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE.
Author information
Abstract
The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that Akt inhibitor MK2206, blocks influenza pH1N1 virus infection in vitro. In particular, at non-cytotoxic concentrations MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9 and H5N1 viruses indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.
PMID:
24752266
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24752266
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.
Denisova OV1, S?derholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE.
Author information
Abstract
The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that Akt inhibitor MK2206, blocks influenza pH1N1 virus infection in vitro. In particular, at non-cytotoxic concentrations MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9 and H5N1 viruses indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.
PMID:
24752266
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24752266