tetano
Editor, Senior Moderator
Alzheimers Dement
. 2022 Mar 17.
doi: 10.1002/alz.12644. Online ahead of print.
Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
Lucia Crivelli[SUP] 1 [/SUP], Katie Palmer[SUP] 2 3 [/SUP], Ismael Calandri[SUP] 1 [/SUP], Alla Guekht[SUP] 4 [/SUP], Ettore Beghi[SUP] 5 [/SUP], William Carroll[SUP] 6 [/SUP], Jennifer Frontera[SUP] 7 [/SUP], David García-Azorín[SUP] 8 [/SUP], Erica Westenberg[SUP] 9 [/SUP], Andrea Sylvia Winkler[SUP] 10 [/SUP], Francesca Mangialasche[SUP] 2 3 [/SUP], Ricardo F Allegri[SUP] 1 11 [/SUP], Miia Kivipelto[SUP] 2 3 12 13 14 [/SUP]
Affiliations
Abstract
Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment.
Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed.
Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = -0.94, 95% confidence interval [CI] -1.59, -0.29; P = .0049).
Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.
Keywords: COVID-19; SARS-CoV-2 coronavirus; attention; cognition; cognitive dysfunction; executive functions; neuropsychological test.
. 2022 Mar 17.
doi: 10.1002/alz.12644. Online ahead of print.
Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
Lucia Crivelli[SUP] 1 [/SUP], Katie Palmer[SUP] 2 3 [/SUP], Ismael Calandri[SUP] 1 [/SUP], Alla Guekht[SUP] 4 [/SUP], Ettore Beghi[SUP] 5 [/SUP], William Carroll[SUP] 6 [/SUP], Jennifer Frontera[SUP] 7 [/SUP], David García-Azorín[SUP] 8 [/SUP], Erica Westenberg[SUP] 9 [/SUP], Andrea Sylvia Winkler[SUP] 10 [/SUP], Francesca Mangialasche[SUP] 2 3 [/SUP], Ricardo F Allegri[SUP] 1 11 [/SUP], Miia Kivipelto[SUP] 2 3 12 13 14 [/SUP]
Affiliations
- PMID: 35297561
- DOI: 10.1002/alz.12644
Abstract
Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment.
Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed.
Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = -0.94, 95% confidence interval [CI] -1.59, -0.29; P = .0049).
Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.
Keywords: COVID-19; SARS-CoV-2 coronavirus; attention; cognition; cognitive dysfunction; executive functions; neuropsychological test.