tetano
Editor, Senior Moderator
Alzheimers Res Ther
. 2021 Apr 10;13(1):77.
doi: 10.1186/s13195-021-00820-9.
COVID-19 in adults with dementia: clinical features and risk factors of mortality-a clinical cohort study on 125 patients
Agathe Vrillon[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Elsa Mhanna[SUP] #[/SUP][SUP] 4 [/SUP], Cl?ment Aveneau[SUP] 5 6 [/SUP], Manon Lebozec[SUP] 7 [/SUP], Lina Grosset[SUP] 6 8 [/SUP], Diane Nankam[SUP] 4 [/SUP], Fernanda Albuquerque[SUP] 4 [/SUP], Raphaelle Razou Feroldi[SUP] 4 [/SUP], Barbara Maakaroun[SUP] 4 [/SUP], Iana Pissareva[SUP] 4 [/SUP], Dalenda Cherni Gherissi[SUP] 4 [/SUP], Julien Azuar[SUP] 5 8 9 [/SUP], V?ronique Fran?ois[SUP] 10 [/SUP], Claire Hourr?gue[SUP] 6 8 [/SUP], Julien Dumurgier[SUP] 6 8 [/SUP], Lisette Volpe-Gillot[SUP] 4 [/SUP], Claire Paquet[SUP] 5 6 [/SUP]
Affiliations
Abstract
Background: There is limited evidence on the characteristics and outcome of patients with dementia hospitalised for novel coronavirus infection (COVID-19).
Method: We conducted a prospective study in 2 gerontologic COVID units in Paris, France, from March 14, 2020, to May 7, 2020. Patients with dementia hospitalised for confirmed COVID-19 infection were systematically enrolled. A binary logistic regression analysis was performed to identify factors associated with mortality at 21 days.
Results: We included 125 patients. Median age was 86 (IQI 82-90); 59.4% were female. Most common causes of dementia were Alzheimer's disease, mixed dementia and vascular dementia. 67.2% had ? 2 comorbidities; 40.2% lived in a long-term care facility. The most common symptoms at COVID-19 onset were confusion and delirium (82.4%), asthenia (76.8%) and fever (72.8%) before polypnea (51.2%) and desaturation (50.4%). Falls were frequent at the initial phase of the disease (35.2%). The fatality rate at 21 days was 22.4%. Chronic kidney disease and CRP at admission were independent factors of death. Persisting confusion, mood and behavioural disorders were observed in survivors (19.2%).
Conclusion: COVID-19 in demented individuals is associated with severe outcome in SARS-CoV-2 infection and is characterised by specific clinical features and complications, with confusion and delirium at the forefront. COVID-19 testing should be considered in front of any significant change from baseline.
Keywords: COVID-19; Dementia; Mortality; Prognostic factors; SARS-CoV-2.
. 2021 Apr 10;13(1):77.
doi: 10.1186/s13195-021-00820-9.
COVID-19 in adults with dementia: clinical features and risk factors of mortality-a clinical cohort study on 125 patients
Agathe Vrillon[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Elsa Mhanna[SUP] #[/SUP][SUP] 4 [/SUP], Cl?ment Aveneau[SUP] 5 6 [/SUP], Manon Lebozec[SUP] 7 [/SUP], Lina Grosset[SUP] 6 8 [/SUP], Diane Nankam[SUP] 4 [/SUP], Fernanda Albuquerque[SUP] 4 [/SUP], Raphaelle Razou Feroldi[SUP] 4 [/SUP], Barbara Maakaroun[SUP] 4 [/SUP], Iana Pissareva[SUP] 4 [/SUP], Dalenda Cherni Gherissi[SUP] 4 [/SUP], Julien Azuar[SUP] 5 8 9 [/SUP], V?ronique Fran?ois[SUP] 10 [/SUP], Claire Hourr?gue[SUP] 6 8 [/SUP], Julien Dumurgier[SUP] 6 8 [/SUP], Lisette Volpe-Gillot[SUP] 4 [/SUP], Claire Paquet[SUP] 5 6 [/SUP]
Affiliations
- PMID: 33838684
- DOI: 10.1186/s13195-021-00820-9
Abstract
Background: There is limited evidence on the characteristics and outcome of patients with dementia hospitalised for novel coronavirus infection (COVID-19).
Method: We conducted a prospective study in 2 gerontologic COVID units in Paris, France, from March 14, 2020, to May 7, 2020. Patients with dementia hospitalised for confirmed COVID-19 infection were systematically enrolled. A binary logistic regression analysis was performed to identify factors associated with mortality at 21 days.
Results: We included 125 patients. Median age was 86 (IQI 82-90); 59.4% were female. Most common causes of dementia were Alzheimer's disease, mixed dementia and vascular dementia. 67.2% had ? 2 comorbidities; 40.2% lived in a long-term care facility. The most common symptoms at COVID-19 onset were confusion and delirium (82.4%), asthenia (76.8%) and fever (72.8%) before polypnea (51.2%) and desaturation (50.4%). Falls were frequent at the initial phase of the disease (35.2%). The fatality rate at 21 days was 22.4%. Chronic kidney disease and CRP at admission were independent factors of death. Persisting confusion, mood and behavioural disorders were observed in survivors (19.2%).
Conclusion: COVID-19 in demented individuals is associated with severe outcome in SARS-CoV-2 infection and is characterised by specific clinical features and complications, with confusion and delirium at the forefront. COVID-19 testing should be considered in front of any significant change from baseline.
Keywords: COVID-19; Dementia; Mortality; Prognostic factors; SARS-CoV-2.