tetano
Editor, Senior Moderator
Am Heart J Plus
. 2022 Feb;14:100134.
doi: 10.1016/j.ahjo.2022.100134. Epub 2022 Apr 18.
Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients
Annas Rahman[SUP] 1 [/SUP], Max Ruge[SUP] 2 [/SUP], Alex Hlepas[SUP] 1 [/SUP], Gatha Nair[SUP] 1 [/SUP], Joanne Gomez[SUP] 3 [/SUP], Jeanne du Fay de Lavallaz[SUP] 1 [/SUP], Setri Fugar[SUP] 3 [/SUP], Nusrat Jahan[SUP] 3 [/SUP], Annabelle Santos Volgman[SUP] 3 [/SUP], Kim A Williams[SUP] 3 [/SUP], Anupama Rao[SUP] 3 [/SUP], Karolina Marinescu[SUP] 3 [/SUP], Tisha Suboc[SUP] 3 [/SUP]
Affiliations
Abstract
Study objective: To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF.
Design: Retrospective study.
Setting: Rush University Medical Center.
Participants: Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria.
Interventions: Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyperdynamic (≥70%) LVEF groups.
Main outcome measures: LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI.
Results: There was no difference in 60-day mortality between patients in the reduced LVEF and normal LVEF groups (adjusted odds ratio [aOR] 0.87, p = 0.68). However, patients with an HDLVEF were more likely to die by 60 days compared to patients in the normal LVEF group (aOR 2.63 [CI: 1.36-5.05]; p < 0.01). The HDLVEF group was also at higher risk for 60-day mortality than the reduced LVEF group (aOR 3.34 [CI: 1.39-8.42]; p < 0.01).
Conclusion: The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.
Keywords: COVID-19; COVID-19, coronavirus disease 2019; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; Heart failure; Hyperdynamic; ICU, intensive care unit; LVEF, left ventricular ejection fraction; Left ventricular ejection fraction; MACE, major adverse cardiovascular events; NLVEF, normal left ventricular ejection fraction; RLVEF, reduced left ventricular ejection fraction; SARS-CoV-2; TTE, transthoracic echocardiogram.
. 2022 Feb;14:100134.
doi: 10.1016/j.ahjo.2022.100134. Epub 2022 Apr 18.
Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients
Annas Rahman[SUP] 1 [/SUP], Max Ruge[SUP] 2 [/SUP], Alex Hlepas[SUP] 1 [/SUP], Gatha Nair[SUP] 1 [/SUP], Joanne Gomez[SUP] 3 [/SUP], Jeanne du Fay de Lavallaz[SUP] 1 [/SUP], Setri Fugar[SUP] 3 [/SUP], Nusrat Jahan[SUP] 3 [/SUP], Annabelle Santos Volgman[SUP] 3 [/SUP], Kim A Williams[SUP] 3 [/SUP], Anupama Rao[SUP] 3 [/SUP], Karolina Marinescu[SUP] 3 [/SUP], Tisha Suboc[SUP] 3 [/SUP]
Affiliations
- PMID: 35463197
- PMCID: PMC9013697
- DOI: 10.1016/j.ahjo.2022.100134
Abstract
Study objective: To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF.
Design: Retrospective study.
Setting: Rush University Medical Center.
Participants: Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria.
Interventions: Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyperdynamic (≥70%) LVEF groups.
Main outcome measures: LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI.
Results: There was no difference in 60-day mortality between patients in the reduced LVEF and normal LVEF groups (adjusted odds ratio [aOR] 0.87, p = 0.68). However, patients with an HDLVEF were more likely to die by 60 days compared to patients in the normal LVEF group (aOR 2.63 [CI: 1.36-5.05]; p < 0.01). The HDLVEF group was also at higher risk for 60-day mortality than the reduced LVEF group (aOR 3.34 [CI: 1.39-8.42]; p < 0.01).
Conclusion: The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.
Keywords: COVID-19; COVID-19, coronavirus disease 2019; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; Heart failure; Hyperdynamic; ICU, intensive care unit; LVEF, left ventricular ejection fraction; Left ventricular ejection fraction; MACE, major adverse cardiovascular events; NLVEF, normal left ventricular ejection fraction; RLVEF, reduced left ventricular ejection fraction; SARS-CoV-2; TTE, transthoracic echocardiogram.