tetano
Editor, Senior Moderator
Am J Infect Control
. 2023 Dec 22:S0196-6553(23)00870-2.
doi: 10.1016/j.ajic.2023.12.009. Online ahead of print. The Impact of COVID-19 on Antibiotic Resistance and Clinical Outcomes among Critically Ill Patients
Khaled Al Oweidat[SUP] 1 [/SUP], Ahmad A Toubasi[SUP] 2 [/SUP], Farah A Khraisat[SUP] 3 [/SUP], Moayad N Aldahabi[SUP] 3 [/SUP], Ahmad Alghrabli[SUP] 4 [/SUP], Yasmeen Khater[SUP] 4 [/SUP], Noor Saleh[SUP] 5 [/SUP], Thuraya N Al-Sayegh[SUP] 3 [/SUP], Asma S Albtoosh[SUP] 1 [/SUP]
Affiliations
Background: There is conflicting evidence regarding the impact of the Coronavirus 2019 (COVID-19) pandemic on antimicrobial resistance, with few studies conducted in low- and middle-income countries. We investigated the impact of the COVID-19 pandemic on multidrug resistant organisms (MDROs) among critically ill patients and their clinical outcomes.
Methods: This was a retrospective observational study of patients admitted to the medical Intensive Care Unit (ICU) at Jordan University Hospital and had blood, urine or bronchoalveolar bacterial cultures taken during two time periods: pre-pandemic (i.e., 1/2016 to 1/2019) and pandemic (i.e., 1/2020 to 1/2023). We compared the clinical outcomes (i.e., in-hospital deaths, the need for O[SUB]2[/SUB] devices, intubation, the length of hospital stay and the occurrence of complications) and prevalence of MDROs between the two periods and conducted multivariate analyses.
Results: There were 1,254 patients (479 pre-pandemic and 775 post-pandemic. The percentage of patients who had MDROs was significantly higher among patients with a culture taken during the pandemic (82.4%) compared to before it (17.6%) (P-value=0.000). Multivariate analysis demonstrated that patients cultured during the pandemic were more than 3 times as likely to have a MDRO (OR=3.210; 95%CI: 2.236-4.609).
Conclusion: The increase in MDROs during the COVID-19 pandemic is an alarming threat to public health; thus, investigating the antibiotic resistance situation as the pandemic subsides is crucial.
Keywords: Antibiotic Resistance; COVID-19; Human; Pandemic.
. 2023 Dec 22:S0196-6553(23)00870-2.
doi: 10.1016/j.ajic.2023.12.009. Online ahead of print. The Impact of COVID-19 on Antibiotic Resistance and Clinical Outcomes among Critically Ill Patients
Khaled Al Oweidat[SUP] 1 [/SUP], Ahmad A Toubasi[SUP] 2 [/SUP], Farah A Khraisat[SUP] 3 [/SUP], Moayad N Aldahabi[SUP] 3 [/SUP], Ahmad Alghrabli[SUP] 4 [/SUP], Yasmeen Khater[SUP] 4 [/SUP], Noor Saleh[SUP] 5 [/SUP], Thuraya N Al-Sayegh[SUP] 3 [/SUP], Asma S Albtoosh[SUP] 1 [/SUP]
Affiliations
- PMID: 38142778
- DOI: 10.1016/j.ajic.2023.12.009
Background: There is conflicting evidence regarding the impact of the Coronavirus 2019 (COVID-19) pandemic on antimicrobial resistance, with few studies conducted in low- and middle-income countries. We investigated the impact of the COVID-19 pandemic on multidrug resistant organisms (MDROs) among critically ill patients and their clinical outcomes.
Methods: This was a retrospective observational study of patients admitted to the medical Intensive Care Unit (ICU) at Jordan University Hospital and had blood, urine or bronchoalveolar bacterial cultures taken during two time periods: pre-pandemic (i.e., 1/2016 to 1/2019) and pandemic (i.e., 1/2020 to 1/2023). We compared the clinical outcomes (i.e., in-hospital deaths, the need for O[SUB]2[/SUB] devices, intubation, the length of hospital stay and the occurrence of complications) and prevalence of MDROs between the two periods and conducted multivariate analyses.
Results: There were 1,254 patients (479 pre-pandemic and 775 post-pandemic. The percentage of patients who had MDROs was significantly higher among patients with a culture taken during the pandemic (82.4%) compared to before it (17.6%) (P-value=0.000). Multivariate analysis demonstrated that patients cultured during the pandemic were more than 3 times as likely to have a MDRO (OR=3.210; 95%CI: 2.236-4.609).
Conclusion: The increase in MDROs during the COVID-19 pandemic is an alarming threat to public health; thus, investigating the antibiotic resistance situation as the pandemic subsides is crucial.
Keywords: Antibiotic Resistance; COVID-19; Human; Pandemic.