tetano
Editor, Senior Moderator
Am J Med Sci
. 2025 Jan 7:S0002-9629(25)00001-1.
doi: 10.1016/j.amjms.2025.01.002. Online ahead of print. Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review
Ákos Pethő[SUP] 1 [/SUP], Deján Dobi[SUP] 2 [/SUP], Magdolna Kardos[SUP] 2 [/SUP], Karolina Schnabel[SUP] 3 [/SUP]
Affiliations
Background: In late 2019, the World Health Organization declared Coronavirus disease 2019 a global emergency. Since then, many vaccines have been developed to combat the pandemic. Millions of people have received one of the approved COVID-19 vaccines; unfortunately, some adverse events also have been recorded.
Methods: In the local health system, patients could get either mRNA vaccines (either Pfizer-BioNTech or Moderna), adenoviral vector vaccine (AstraZeneca), or the vaccine based on inactivated virus (Sinovac). We investigated what immune-mediated adverse events occurred in our department after the COVID-19 vaccination.
Results: We evaluated six patients from our center who received mRNA vaccines and developed suspected immune-mediated adverse events. The immune-mediated adverse events are characterized by de novo or relapsing glomerular diseases and are further confirmed with percutaneous kidney biopsies. During A follow-up of more than two years, remission occurred in five patients, and glomerulonephritis persisted in one of them.
Conclusion: Vaccinations are pivotal in effectively protecting and preventing various epidemics. As such, it is essential to maintain a high level of vigilance concerning post-vaccination adverse events. This heightened level of suspicion leads to earlier detection, better understanding, and optimal prevention and management of these events. To this end, developing a specific vaccine/patient risk profile is necessary to categorize the target population selectively.
Keywords: COVID-19 vaccine; adverse events post-vaccine; glomerulonephritis; immunological; mRNA vaccines; viral vector-based vaccines.
. 2025 Jan 7:S0002-9629(25)00001-1.
doi: 10.1016/j.amjms.2025.01.002. Online ahead of print. Unexpected renal side effects of mRNA COVID-19 vaccines; a single-center experience and short review
Ákos Pethő[SUP] 1 [/SUP], Deján Dobi[SUP] 2 [/SUP], Magdolna Kardos[SUP] 2 [/SUP], Karolina Schnabel[SUP] 3 [/SUP]
Affiliations
- PMID: 39788422
- DOI: 10.1016/j.amjms.2025.01.002
Background: In late 2019, the World Health Organization declared Coronavirus disease 2019 a global emergency. Since then, many vaccines have been developed to combat the pandemic. Millions of people have received one of the approved COVID-19 vaccines; unfortunately, some adverse events also have been recorded.
Methods: In the local health system, patients could get either mRNA vaccines (either Pfizer-BioNTech or Moderna), adenoviral vector vaccine (AstraZeneca), or the vaccine based on inactivated virus (Sinovac). We investigated what immune-mediated adverse events occurred in our department after the COVID-19 vaccination.
Results: We evaluated six patients from our center who received mRNA vaccines and developed suspected immune-mediated adverse events. The immune-mediated adverse events are characterized by de novo or relapsing glomerular diseases and are further confirmed with percutaneous kidney biopsies. During A follow-up of more than two years, remission occurred in five patients, and glomerulonephritis persisted in one of them.
Conclusion: Vaccinations are pivotal in effectively protecting and preventing various epidemics. As such, it is essential to maintain a high level of vigilance concerning post-vaccination adverse events. This heightened level of suspicion leads to earlier detection, better understanding, and optimal prevention and management of these events. To this end, developing a specific vaccine/patient risk profile is necessary to categorize the target population selectively.
Keywords: COVID-19 vaccine; adverse events post-vaccine; glomerulonephritis; immunological; mRNA vaccines; viral vector-based vaccines.