tetano
Editor, Senior Moderator
Am J Ophthalmol Case Rep
. 2020 Dec;20:100958.
doi: 10.1016/j.ajoc.2020.100958. Epub 2020 Oct 9.
Bilateral macular hemorrhage in a patient with COVID-19
Rossella D'Aloisio[SUP] 1 [/SUP], Vincenzo Nasillo[SUP] 2 [/SUP], Matteo Gironi[SUP] 3 [/SUP], Rodolfo Mastropasqua[SUP] 3 [/SUP]
Affiliations
Abstract
Purpose: We report a case of a patient with a known hereditary spherocytosis who developed a bilateral macular hemorrhage in concurrence with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related respiratory syndrome.
Observations: Blood tests showed severe hemolytic anemia. Interestingly, the peripheral blood smear demonstrated a mixed pathogenesis of the hemolytic process (cold-agglutinin-mediated and non-immune-mediated due to spherocytosis).
Conclusions and importance: We argue that SARS-CoV-2 could have triggered the hemolytic process, which led to retinal hemorrhages due to endothelial anoxia from the low oxygen carrying capacity.
Keywords: Hereditary spherocytosis; Macular hemorrhage; SARS-CoV-2.
. 2020 Dec;20:100958.
doi: 10.1016/j.ajoc.2020.100958. Epub 2020 Oct 9.
Bilateral macular hemorrhage in a patient with COVID-19
Rossella D'Aloisio[SUP] 1 [/SUP], Vincenzo Nasillo[SUP] 2 [/SUP], Matteo Gironi[SUP] 3 [/SUP], Rodolfo Mastropasqua[SUP] 3 [/SUP]
Affiliations
- PMID: 33073058
- PMCID: PMC7546668
- DOI: 10.1016/j.ajoc.2020.100958
Abstract
Purpose: We report a case of a patient with a known hereditary spherocytosis who developed a bilateral macular hemorrhage in concurrence with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related respiratory syndrome.
Observations: Blood tests showed severe hemolytic anemia. Interestingly, the peripheral blood smear demonstrated a mixed pathogenesis of the hemolytic process (cold-agglutinin-mediated and non-immune-mediated due to spherocytosis).
Conclusions and importance: We argue that SARS-CoV-2 could have triggered the hemolytic process, which led to retinal hemorrhages due to endothelial anoxia from the low oxygen carrying capacity.
Keywords: Hereditary spherocytosis; Macular hemorrhage; SARS-CoV-2.