tetano
Editor, Senior Moderator
Am J Reprod Immunol
. 2020 Jun 9;e13285.
doi: 10.1111/aji.13285. Online ahead of print.
Immunological Environment Shifts During Pregnancy May Affect the Risk of Developing Severe Complications in COVID-19 Patients
Alexey Sarapultsev[SUP] 1 [/SUP], Petr Sarapultsev[SUP] 1 [/SUP]
Affiliations
Abstract
Problem: The 2019 novel coronavirus disease (COVID-19) has been rapidly spreading out in China and all over the world. Because of the immune reaction severity, 20.3% of COVID-19 patients required intensive care unit, and 32.8% presented with acute respiratory distress syndrome (ARDS). In this regard, the urgent question that needs to be addressed promptly includes whether pregnant women with COVID-19 will develop distinct symptoms from non-pregnant and what are the reasons for that.
Results: According to the literature data, clinical characteristics of pregnant women with COVID-19 were similar to those of non-pregnant adults and no significant differences in gestational age, postpartum hemorrhage, and perineal resection rates between pregnant women with and without COVID-19 were found. There is also a tendency that COVID-19 disease progresses slowly in pregnant women and does not often result in fatal pregnancy complications.
Conclusions: The predominant Th2-type immunity and the action of T-regs can play an important role in preventing the excess systemic inflammatory reaction and the development of life-threatening complications as ARDS and MODS in COVID-19 patients. This suggests a search for new drugs aimed at the suppression of effector functions and induction of tolerance, which will reduce the frequency of life-threatening complications, including ARDS.
Keywords: COVID-19; Th cells; complications; immunological shift; immunology; pregnancy.
This article is protected by copyright. All rights reserved.
. 2020 Jun 9;e13285.
doi: 10.1111/aji.13285. Online ahead of print.
Immunological Environment Shifts During Pregnancy May Affect the Risk of Developing Severe Complications in COVID-19 Patients
Alexey Sarapultsev[SUP] 1 [/SUP], Petr Sarapultsev[SUP] 1 [/SUP]
Affiliations
- PMID: 32516444
- DOI: 10.1111/aji.13285
Abstract
Problem: The 2019 novel coronavirus disease (COVID-19) has been rapidly spreading out in China and all over the world. Because of the immune reaction severity, 20.3% of COVID-19 patients required intensive care unit, and 32.8% presented with acute respiratory distress syndrome (ARDS). In this regard, the urgent question that needs to be addressed promptly includes whether pregnant women with COVID-19 will develop distinct symptoms from non-pregnant and what are the reasons for that.
Results: According to the literature data, clinical characteristics of pregnant women with COVID-19 were similar to those of non-pregnant adults and no significant differences in gestational age, postpartum hemorrhage, and perineal resection rates between pregnant women with and without COVID-19 were found. There is also a tendency that COVID-19 disease progresses slowly in pregnant women and does not often result in fatal pregnancy complications.
Conclusions: The predominant Th2-type immunity and the action of T-regs can play an important role in preventing the excess systemic inflammatory reaction and the development of life-threatening complications as ARDS and MODS in COVID-19 patients. This suggests a search for new drugs aimed at the suppression of effector functions and induction of tolerance, which will reduce the frequency of life-threatening complications, including ARDS.
Keywords: COVID-19; Th cells; complications; immunological shift; immunology; pregnancy.
This article is protected by copyright. All rights reserved.