tetano
Editor, Senior Moderator
Am J Reprod Immunol
. 2022 Feb 11.
doi: 10.1111/aji.13528. Online ahead of print.
The risk of intrauterine exposure to SARS-CoV-2 in female COVID-19 patients: a comprehensive Review
Guo-Hua Zhu[SUP] 1 2 [/SUP], Lu Liu[SUP] 1 2 [/SUP], Xi-Xi Huang[SUP] 1 2 [/SUP], Da-Jin Li[SUP] 1 2 [/SUP], Yi-Zhun Zhu[SUP] 3 [/SUP], Xin Lu[SUP] 2 [/SUP], Mei-Rong Du[SUP] 1 2 3 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that has caused fatal infectious diseases and global spread. This novel coronavirus attacks target cells through the interaction of spike protein and angiotensin-converting enzyme II (ACE2), leading to different clinical symptoms. However, for a successful pregnancy, a well-established in-uterine environment includes a specific immune environment, and multi-interactions between specific cell types are prerequisites. The immune-related changes in patients infected with novel coronavirus could interfere with the immune microenvironment in the uterus, leading to fetal loss. We first reviewed the intrauterine environment in the normal development process and the possible pregnancy outcome in the infection state. Then, we summarized the immune response induced by SARS-CoV-2 in patients and analyzed the changes in ACE2 expression in the female reproductive system. Finally, the present observational evidence of infection in pregnant women was also reviewed. This article is protected by copyright. All rights reserved.
Keywords: angiotensin-converting enzyme 2; endometrium; fertility; severe acute respiratory syndrome coronavirus 2.
. 2022 Feb 11.
doi: 10.1111/aji.13528. Online ahead of print.
The risk of intrauterine exposure to SARS-CoV-2 in female COVID-19 patients: a comprehensive Review
Guo-Hua Zhu[SUP] 1 2 [/SUP], Lu Liu[SUP] 1 2 [/SUP], Xi-Xi Huang[SUP] 1 2 [/SUP], Da-Jin Li[SUP] 1 2 [/SUP], Yi-Zhun Zhu[SUP] 3 [/SUP], Xin Lu[SUP] 2 [/SUP], Mei-Rong Du[SUP] 1 2 3 4 [/SUP]
Affiliations
- PMID: 35148017
- DOI: 10.1111/aji.13528
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that has caused fatal infectious diseases and global spread. This novel coronavirus attacks target cells through the interaction of spike protein and angiotensin-converting enzyme II (ACE2), leading to different clinical symptoms. However, for a successful pregnancy, a well-established in-uterine environment includes a specific immune environment, and multi-interactions between specific cell types are prerequisites. The immune-related changes in patients infected with novel coronavirus could interfere with the immune microenvironment in the uterus, leading to fetal loss. We first reviewed the intrauterine environment in the normal development process and the possible pregnancy outcome in the infection state. Then, we summarized the immune response induced by SARS-CoV-2 in patients and analyzed the changes in ACE2 expression in the female reproductive system. Finally, the present observational evidence of infection in pregnant women was also reviewed. This article is protected by copyright. All rights reserved.
Keywords: angiotensin-converting enzyme 2; endometrium; fertility; severe acute respiratory syndrome coronavirus 2.