tetano
Editor, Senior Moderator
Am J Respir Cell Mol Biol
. 2021 Apr 2.
doi: 10.1165/rcmb.2020-0236TR. Online ahead of print.
The Role of Obesity in the Immunopathogenesis of COVID-19 Respiratory Disease and Critical Illness
Stephen J Kuperberg[SUP] 1 [/SUP], Brianne Navetta-Modrov[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus Disease 2019, (COVID-19), the clinical syndrome caused by the SARS-COV-2 virus is currently a global health pandemic with substantial morbidity and mortality. COVID-19 has cast a shadow on nearly every aspect of society, straining health systems and economies across the world. While it is widely accepted that a close relationship exists between obesity, cardiovascular disease and metabolic disorders on infection, we are only beginning to understand ways in which the immunological sequelae of obesity functions as a predisposing factor related to poor clinical outcomes in COVID-19. As both the innate and adaptive immune systems are each primed by obesity, alteration of key pathways results in both an immunosuppressed and hyperinflammatory state. The present review will discuss the cellular and molecular immunology of obesity in the context of its role as a risk factor for severe COVID-19, discuss the role of cytokine storm, and draw parallels to prior viral epidemics such as SARS, MERS-COV and H1N1. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: COVID; adaptive; cytokine; innate; obesity.
. 2021 Apr 2.
doi: 10.1165/rcmb.2020-0236TR. Online ahead of print.
The Role of Obesity in the Immunopathogenesis of COVID-19 Respiratory Disease and Critical Illness
Stephen J Kuperberg[SUP] 1 [/SUP], Brianne Navetta-Modrov[SUP] 2 [/SUP]
Affiliations
- PMID: 33797351
- DOI: 10.1165/rcmb.2020-0236TR
Abstract
Coronavirus Disease 2019, (COVID-19), the clinical syndrome caused by the SARS-COV-2 virus is currently a global health pandemic with substantial morbidity and mortality. COVID-19 has cast a shadow on nearly every aspect of society, straining health systems and economies across the world. While it is widely accepted that a close relationship exists between obesity, cardiovascular disease and metabolic disorders on infection, we are only beginning to understand ways in which the immunological sequelae of obesity functions as a predisposing factor related to poor clinical outcomes in COVID-19. As both the innate and adaptive immune systems are each primed by obesity, alteration of key pathways results in both an immunosuppressed and hyperinflammatory state. The present review will discuss the cellular and molecular immunology of obesity in the context of its role as a risk factor for severe COVID-19, discuss the role of cytokine storm, and draw parallels to prior viral epidemics such as SARS, MERS-COV and H1N1. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: COVID; adaptive; cytokine; innate; obesity.