tetano
Editor, Senior Moderator
Am J Transplant
. 2022 Jul 8.
doi: 10.1111/ajt.17141. Online ahead of print.
Incidence and severity of SARS-CoV-2 infections in liver and kidney transplant recipients in the post-vaccination era: Real-life data from Denmark
Sebastian Rask Hamm[SUP] 1 [/SUP], Omid Rezahosseini[SUP] 1 [/SUP], Dina Leth Møller[SUP] 1 [/SUP], Josefine Amalie Loft[SUP] 1 [/SUP], Johan Runge Poulsen[SUP] 1 [/SUP], Jenny Dahl Knudsen[SUP] 2 [/SUP], Martin Schou Pedersen[SUP] 2 [/SUP], Kristian Schønning[SUP] 2 [/SUP], Zitta Barrella Harboe[SUP] 3 4 [/SUP], Allan Rasmussen[SUP] 5 [/SUP], Søren Schwartz Sørensen[SUP] 4 6 [/SUP], Susanne Dam Nielsen[SUP] 1 5 6 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been associated with high risk of adverse outcomes in solid organ transplant (SOT) recipients in the pre-vaccination era. In this retrospective cohort study, we examined the incidence and severity of COVID-19 in kidney and liver transplant recipients in Denmark in the post-vaccination era, from December 27, 2020, to December 27, 2021. We included 1428 SOT recipients with 143 cases of first positive SARS-CoV-2 PCR test. The cumulative incidence of first positive SARS-CoV-2 PCR test one year after initiation of vaccination was 10.4% (95% CI: 8.8-12.0), and the incidence was higher in kidney than in liver transplant recipients (11.6% [95% CI: 9.4-13.8] vs. 7.4% [95% CI: 5.1-9.8], p=0.009). After the first positive SARS-CoV-2 PCR test, the hospitalization rate was 31.5% (95% CI: 23.9-39.1), and 30-day all-cause mortality was 3.7% (95% CI: 0.5-6.8). Hospitalization was lower in vaccinated than in unvaccinated SOT recipients (26.4% [95% CI: 18.1-34.6] vs. 48.5% [95% CI: 31.4-65.5], p=0.011), as was mortality (1.8% [95% CI: 0.0-4.3] vs. 9.1% [95% CI: 0.0-18.9], p=0.047). In conclusion, SOT recipients remain at high risk of adverse outcomes after SARS-CoV-2 infections, with a lower risk observed in vaccinated than in unvaccinated SOT recipients.
. 2022 Jul 8.
doi: 10.1111/ajt.17141. Online ahead of print.
Incidence and severity of SARS-CoV-2 infections in liver and kidney transplant recipients in the post-vaccination era: Real-life data from Denmark
Sebastian Rask Hamm[SUP] 1 [/SUP], Omid Rezahosseini[SUP] 1 [/SUP], Dina Leth Møller[SUP] 1 [/SUP], Josefine Amalie Loft[SUP] 1 [/SUP], Johan Runge Poulsen[SUP] 1 [/SUP], Jenny Dahl Knudsen[SUP] 2 [/SUP], Martin Schou Pedersen[SUP] 2 [/SUP], Kristian Schønning[SUP] 2 [/SUP], Zitta Barrella Harboe[SUP] 3 4 [/SUP], Allan Rasmussen[SUP] 5 [/SUP], Søren Schwartz Sørensen[SUP] 4 6 [/SUP], Susanne Dam Nielsen[SUP] 1 5 6 [/SUP]
Affiliations
- PMID: 35801693
- DOI: 10.1111/ajt.17141
Abstract
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been associated with high risk of adverse outcomes in solid organ transplant (SOT) recipients in the pre-vaccination era. In this retrospective cohort study, we examined the incidence and severity of COVID-19 in kidney and liver transplant recipients in Denmark in the post-vaccination era, from December 27, 2020, to December 27, 2021. We included 1428 SOT recipients with 143 cases of first positive SARS-CoV-2 PCR test. The cumulative incidence of first positive SARS-CoV-2 PCR test one year after initiation of vaccination was 10.4% (95% CI: 8.8-12.0), and the incidence was higher in kidney than in liver transplant recipients (11.6% [95% CI: 9.4-13.8] vs. 7.4% [95% CI: 5.1-9.8], p=0.009). After the first positive SARS-CoV-2 PCR test, the hospitalization rate was 31.5% (95% CI: 23.9-39.1), and 30-day all-cause mortality was 3.7% (95% CI: 0.5-6.8). Hospitalization was lower in vaccinated than in unvaccinated SOT recipients (26.4% [95% CI: 18.1-34.6] vs. 48.5% [95% CI: 31.4-65.5], p=0.011), as was mortality (1.8% [95% CI: 0.0-4.3] vs. 9.1% [95% CI: 0.0-18.9], p=0.047). In conclusion, SOT recipients remain at high risk of adverse outcomes after SARS-CoV-2 infections, with a lower risk observed in vaccinated than in unvaccinated SOT recipients.