tetano
Editor, Senior Moderator
Am J Trop Med Hyg
. 2021 Sep 20;tpmd210542.
doi: 10.4269/ajtmh.21-0542. Online ahead of print.
Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants
Benjamin W Neuman[SUP] 1 2 [/SUP], Wesley A Brashear[SUP] 3 [/SUP], Marcel Brun[SUP] 4 [/SUP], Sankar P Chaki[SUP] 1 [/SUP], Rebecca S B Fischer[SUP] 5 [/SUP], Sierra J Guidry[SUP] 1 [/SUP], Joshua E Hill[SUP] 4 [/SUP], Andrew E Hillhouse[SUP] 3 6 [/SUP], Charles D Johnson[SUP] 4 [/SUP], Melissa M Kahl-McDonagh[SUP] 1 [/SUP], Richard P Metz[SUP] 4 [/SUP], Allison C Rice-Ficht[SUP] 1 6 [/SUP], Jennifer A Shuford[SUP] 7 [/SUP], Tiffany A Skaggs[SUP] 8 [/SUP], Matthew A Stull[SUP] 4 [/SUP], David W Threadgill[SUP] 3 6 [/SUP], Yao Akpalu[SUP] 9 [/SUP], Kurt Zuelke[SUP] 1 [/SUP]
Affiliations
Abstract
To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
. 2021 Sep 20;tpmd210542.
doi: 10.4269/ajtmh.21-0542. Online ahead of print.
Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants
Benjamin W Neuman[SUP] 1 2 [/SUP], Wesley A Brashear[SUP] 3 [/SUP], Marcel Brun[SUP] 4 [/SUP], Sankar P Chaki[SUP] 1 [/SUP], Rebecca S B Fischer[SUP] 5 [/SUP], Sierra J Guidry[SUP] 1 [/SUP], Joshua E Hill[SUP] 4 [/SUP], Andrew E Hillhouse[SUP] 3 6 [/SUP], Charles D Johnson[SUP] 4 [/SUP], Melissa M Kahl-McDonagh[SUP] 1 [/SUP], Richard P Metz[SUP] 4 [/SUP], Allison C Rice-Ficht[SUP] 1 6 [/SUP], Jennifer A Shuford[SUP] 7 [/SUP], Tiffany A Skaggs[SUP] 8 [/SUP], Matthew A Stull[SUP] 4 [/SUP], David W Threadgill[SUP] 3 6 [/SUP], Yao Akpalu[SUP] 9 [/SUP], Kurt Zuelke[SUP] 1 [/SUP]
Affiliations
- PMID: 34544043
- DOI: 10.4269/ajtmh.21-0542
Abstract
To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.