tetano
Editor, Senior Moderator
Bull Exp Biol Med. 2014 Jun 10. [Epub ahead of print]
Amino Acid Derivatives of Adamantane Carbocycle are Capable of Inhibiting Replication of Highly Virulent Avian Influenza A/H5N1 Virus.
Deryabin PG1, Garaev TM, Finogenova MP, Botikov AG, Shibnev VA.
Author information
Abstract
We studied the capacity amino acid derivatives of adamantane to inhibit replication of highly virulent avian influenza A/duck/Novosibirsk/56/05 (H5N1) virus in cultures of swine embryonic kidney cells. Amino acid derivatives of adamantane H-His-Rem and Ad(CH2-Ser-OMe)2 were characterized by lower toxicity than remantadine previously used in the treatment of influenza. Histidine-containing adamantane derivative (H-His-Rem) was the most effective and low-toxic inhibitor of influenza А/H5N1 virus replication and can be recommended for clinical trials to produce a preparation for the treatment and prevention of influenza.
PMID:
24909717
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24909717
Amino Acid Derivatives of Adamantane Carbocycle are Capable of Inhibiting Replication of Highly Virulent Avian Influenza A/H5N1 Virus.
Deryabin PG1, Garaev TM, Finogenova MP, Botikov AG, Shibnev VA.
Author information
Abstract
We studied the capacity amino acid derivatives of adamantane to inhibit replication of highly virulent avian influenza A/duck/Novosibirsk/56/05 (H5N1) virus in cultures of swine embryonic kidney cells. Amino acid derivatives of adamantane H-His-Rem and Ad(CH2-Ser-OMe)2 were characterized by lower toxicity than remantadine previously used in the treatment of influenza. Histidine-containing adamantane derivative (H-His-Rem) was the most effective and low-toxic inhibitor of influenza А/H5N1 virus replication and can be recommended for clinical trials to produce a preparation for the treatment and prevention of influenza.
PMID:
24909717
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24909717