tetano
Editor, Senior Moderator
Pediatr Crit Care Med. 2012 May 16. [Epub ahead of print]
An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa.
Ghani AS, Morrow BM, Hardie DR, Argent AC.
Source
From the Red Cross War Memorial Children's Hospital (ASAG, ACA), Cape Town, South Africa; the University of Cape Town (BMM, ACA), School of Child and Adolescent Health, Cape Town, South Africa; and the Virology Laboratory of the National Health Laboratory Services (DRH), Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa.
Abstract
OBJECTIVES:
To describe the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections.
DESIGN:
Retrospective descriptive study.
SETTING:
Pediatric intensive care unit in a tertiary pediatric hospital situated in Cape Town, South Africa.
PATIENTS:
All children (n = 195; 20% pediatric intensive care unit admissions) with positive respiratory viral isolates between April 1 and December 31, 2009.
INTERVENTIONS:
None.
MEASUREMENTS AND MAIN RESULTS:
Demographic, clinical, laboratory, and outcome data were recorded from medical folders. Complete data were available for 175 patients (median age [interquartile range] 4.7 months [2.3-12.9 months]; 49% male). One hundred four (59.4%) patients had comorbid conditions; 30 (17%) were HIV-infected. Rhinovirus (n = 76 [39%]), respiratory syncytial virus (n = 54 [27.7%]), adenovirus (n = 30 [15.4%]), influenza A (n = 26 [13.3%]), parainfluenza (n = 23 [11.8%]), and human metapneumovirus (n = 12 [6.2%]) were most commonly isolated. Ninety-five infections (51.4%) were isolated >48 hrs after admission. Seasonal patterns were identified for respiratory syncytial virus, human metapneumovirus, and influenza A, whereas others occurred throughout the year. Twenty-five patients (14.3%) had more than one viral isolate. Presumed bacterial coinfection, which occurred in 68 (39%) patients (18 [26.5%] HIV-infected), was associated with significantly longer pediatric intensive care unit and hospital stays but not with mortality. Twenty patients died (11%, standardized mortality ratio 0.64). High Pediatric Index of Mortality scores, HIV exposure and infection, nosocomial infection, and influenza A infection were associated with mortality.
CONCLUSIONS:
Viral respiratory tract infection is common in this pediatric intensive care unit associated with significant morbidity and mortality, which may relate to the high burden of comorbidity and HIV.
PMID:
22596071
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22596071
An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa.
Ghani AS, Morrow BM, Hardie DR, Argent AC.
Source
From the Red Cross War Memorial Children's Hospital (ASAG, ACA), Cape Town, South Africa; the University of Cape Town (BMM, ACA), School of Child and Adolescent Health, Cape Town, South Africa; and the Virology Laboratory of the National Health Laboratory Services (DRH), Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa.
Abstract
OBJECTIVES:
To describe the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections.
DESIGN:
Retrospective descriptive study.
SETTING:
Pediatric intensive care unit in a tertiary pediatric hospital situated in Cape Town, South Africa.
PATIENTS:
All children (n = 195; 20% pediatric intensive care unit admissions) with positive respiratory viral isolates between April 1 and December 31, 2009.
INTERVENTIONS:
None.
MEASUREMENTS AND MAIN RESULTS:
Demographic, clinical, laboratory, and outcome data were recorded from medical folders. Complete data were available for 175 patients (median age [interquartile range] 4.7 months [2.3-12.9 months]; 49% male). One hundred four (59.4%) patients had comorbid conditions; 30 (17%) were HIV-infected. Rhinovirus (n = 76 [39%]), respiratory syncytial virus (n = 54 [27.7%]), adenovirus (n = 30 [15.4%]), influenza A (n = 26 [13.3%]), parainfluenza (n = 23 [11.8%]), and human metapneumovirus (n = 12 [6.2%]) were most commonly isolated. Ninety-five infections (51.4%) were isolated >48 hrs after admission. Seasonal patterns were identified for respiratory syncytial virus, human metapneumovirus, and influenza A, whereas others occurred throughout the year. Twenty-five patients (14.3%) had more than one viral isolate. Presumed bacterial coinfection, which occurred in 68 (39%) patients (18 [26.5%] HIV-infected), was associated with significantly longer pediatric intensive care unit and hospital stays but not with mortality. Twenty patients died (11%, standardized mortality ratio 0.64). High Pediatric Index of Mortality scores, HIV exposure and infection, nosocomial infection, and influenza A infection were associated with mortality.
CONCLUSIONS:
Viral respiratory tract infection is common in this pediatric intensive care unit associated with significant morbidity and mortality, which may relate to the high burden of comorbidity and HIV.
PMID:
22596071
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22596071