tetano
Editor, Senior Moderator
J Med Virol. 2016 Mar 31. doi: 10.1002/jmv.24539. [Epub ahead of print]
[h=1]An outbreak of influenza-like illness investigated during august 2013 near Indo-China border of Arunachal Pradesh, Northeast India.[/h] Biswas D[SUP]1[/SUP], Buragohain M[SUP]1[/SUP], Yadav K[SUP]1[/SUP], Dutta M[SUP]1[/SUP], Sarmah K[SUP]1[/SUP], Baruah PJ[SUP]1[/SUP], Borkakoty B[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During August 2013, an outbreak of influenza-like illnesses (ILI) was investigated in Monigong area, near Indo-China border of Arunachal Pradesh, Northeast India. Influenza type A/H3N2 was detected by RT-PCR in 33.3% (8/24) of ILI cases. Sequence analysis of HA and NA genes revealed eight and five amino acid substitutions respectively in Monigong H3N2 (Mo/H3N2) strains as compared to vaccine strain A/Victoria/361/2011. Four non-synonymous substitutions, three localizing at antigenic sites T144A, A; R158G, B; L173S, D and one H9Y in close proximity to a potential glycosylation site aa8 in HA1 domain along with the substitution T329N in NA are likely to influence the antigenicity/virulence of Mo/H3N2 viruses. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] H3N2; ILI; Influenza
PMID: 27035572 [PubMed - as supplied by publisher]
[h=1]An outbreak of influenza-like illness investigated during august 2013 near Indo-China border of Arunachal Pradesh, Northeast India.[/h] Biswas D[SUP]1[/SUP], Buragohain M[SUP]1[/SUP], Yadav K[SUP]1[/SUP], Dutta M[SUP]1[/SUP], Sarmah K[SUP]1[/SUP], Baruah PJ[SUP]1[/SUP], Borkakoty B[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During August 2013, an outbreak of influenza-like illnesses (ILI) was investigated in Monigong area, near Indo-China border of Arunachal Pradesh, Northeast India. Influenza type A/H3N2 was detected by RT-PCR in 33.3% (8/24) of ILI cases. Sequence analysis of HA and NA genes revealed eight and five amino acid substitutions respectively in Monigong H3N2 (Mo/H3N2) strains as compared to vaccine strain A/Victoria/361/2011. Four non-synonymous substitutions, three localizing at antigenic sites T144A, A; R158G, B; L173S, D and one H9Y in close proximity to a potential glycosylation site aa8 in HA1 domain along with the substitution T329N in NA are likely to influence the antigenicity/virulence of Mo/H3N2 viruses. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] H3N2; ILI; Influenza
PMID: 27035572 [PubMed - as supplied by publisher]