tetano
Editor, Senior Moderator
Animals (Basel)
. 2022 Feb 4;12(3):378.
doi: 10.3390/ani12030378.
Diversity of Coronaviruses with Particular Attention to the Interspecies Transmission of SARS-CoV-2
Awad A Shehata[SUP] 1 2 [/SUP], Youssef A Attia[SUP] 3 4 5 [/SUP], Md Tanvir Rahman[SUP] 6 [/SUP], Shereen Basiouni[SUP] 7 [/SUP], Hesham R El-Seedi[SUP] 8 9 [/SUP], Esam I Azhar[SUP] 10 [/SUP], Asmaa F Khafaga[SUP] 11 [/SUP], Hafez M Hafez[SUP] 12 [/SUP]
Affiliations
Abstract
In December 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in China with serious impacts on global health and economy that is still ongoing. Although interspecies transmission of coronaviruses is common and well documented, each coronavirus has a narrowly restricted host range. Coronaviruses utilize different receptors to mediate membrane fusion and replication in the cell cytoplasm. The interplay between the receptor-binding domain (RBD) of coronaviruses and their coevolution are determinants for host susceptibility. The recently emerged SARS-CoV-2 caused the coronavirus disease 2019 (COVID-19) pandemic and has also been reported in domestic and wild animals, raising the question about the responsibility of animals in virus evolution. Additionally, the COVID-19 pandemic might also substantially have an impact on animal production for a long time. In the present review, we discussed the diversity of coronaviruses in animals and thus the diversity of their receptors. Moreover, the determinants of the susceptibility of SARS-CoV-2 in several animals, with special reference to the current evidence of SARS-CoV-2 in animals, were highlighted. Finally, we shed light on the urgent demand for the implementation of the One Health concept as a collaborative global approach to mitigate the threat for both humans and animals.
Keywords: COVID-19; One Health; SARS-CoV-2; angiotensin-converting enzyme 2; interspecies transmission; receptors.
. 2022 Feb 4;12(3):378.
doi: 10.3390/ani12030378.
Diversity of Coronaviruses with Particular Attention to the Interspecies Transmission of SARS-CoV-2
Awad A Shehata[SUP] 1 2 [/SUP], Youssef A Attia[SUP] 3 4 5 [/SUP], Md Tanvir Rahman[SUP] 6 [/SUP], Shereen Basiouni[SUP] 7 [/SUP], Hesham R El-Seedi[SUP] 8 9 [/SUP], Esam I Azhar[SUP] 10 [/SUP], Asmaa F Khafaga[SUP] 11 [/SUP], Hafez M Hafez[SUP] 12 [/SUP]
Affiliations
- PMID: 35158701
- DOI: 10.3390/ani12030378
Abstract
In December 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in China with serious impacts on global health and economy that is still ongoing. Although interspecies transmission of coronaviruses is common and well documented, each coronavirus has a narrowly restricted host range. Coronaviruses utilize different receptors to mediate membrane fusion and replication in the cell cytoplasm. The interplay between the receptor-binding domain (RBD) of coronaviruses and their coevolution are determinants for host susceptibility. The recently emerged SARS-CoV-2 caused the coronavirus disease 2019 (COVID-19) pandemic and has also been reported in domestic and wild animals, raising the question about the responsibility of animals in virus evolution. Additionally, the COVID-19 pandemic might also substantially have an impact on animal production for a long time. In the present review, we discussed the diversity of coronaviruses in animals and thus the diversity of their receptors. Moreover, the determinants of the susceptibility of SARS-CoV-2 in several animals, with special reference to the current evidence of SARS-CoV-2 in animals, were highlighted. Finally, we shed light on the urgent demand for the implementation of the One Health concept as a collaborative global approach to mitigate the threat for both humans and animals.
Keywords: COVID-19; One Health; SARS-CoV-2; angiotensin-converting enzyme 2; interspecies transmission; receptors.