tetano
Editor, Senior Moderator
Ann Hematol
. 2023 Aug 15.
doi: 10.1007/s00277-023-05407-y. Online ahead of print. Association between ABO blood group/genotype and COVID-19 in a Japanese population
Tatsuya Kusumoto[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Mayuko Watase[SUP] 4 [/SUP], Kaori Sakurai[SUP] 1 [/SUP], Takanori Asakura[SUP] 1 5 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 6 [/SUP], Naoki Hasegawa[SUP] 7 [/SUP], Norihiro Harada[SUP] 8 [/SUP], Tetsuya Ueda[SUP] 9 [/SUP], Soichiro Ueda[SUP] 10 [/SUP], Takashi Ishiguro[SUP] 11 [/SUP], Ken Arimura[SUP] 12 [/SUP], Fukuki Saito[SUP] 13 [/SUP], Takashi Yoshiyama[SUP] 14 [/SUP], Yasushi Nakano[SUP] 15 [/SUP], Yoshikazu Mutoh[SUP] 16 [/SUP], Yusuke Suzuki[SUP] 5 [/SUP], Ryuya Edahiro[SUP] 17 [/SUP], Hirohito Sano[SUP] 18 [/SUP], Yasunori Sato[SUP] 19 [/SUP], Yukinori Okada[SUP] 20 21 22 23 24 25 [/SUP], Ryuji Koike[SUP] 26 [/SUP], Yuko Kitagawa[SUP] 27 [/SUP], Katsushi Tokunaga[SUP] 28 [/SUP], Akinori Kimura[SUP] 29 [/SUP], Seiya Imoto[SUP] 30 [/SUP], Satoru Miyano[SUP] 31 [/SUP], Seishi Ogawa[SUP] 32 33 34 [/SUP], Takanori Kanai[SUP] 35 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
An association between coronavirus disease 2019 (COVID-19) and the ABO blood group has been reported. However, such an association has not been studied in the Japanese population on a large scale. Little is known about the association between COVID-19 and ABO genotype. This study investigated the association between COVID-19 and ABO blood group/genotype in a large Japanese population. All Japanese patients diagnosed with COVID-19 were recruited through the Japan COVID-19 Task Force between February 2020 and October 2021. We conducted a retrospective cohort study involving 1790 Japanese COVID-19 patients whose DNA was used for a genome-wide association study. We compared the ABO blood group/genotype in a healthy population (n = 611, control) and COVID-19 patients and then analyzed their associations and clinical outcomes. Blood group A was significantly more prevalent (41.6% vs. 36.8%; P = 0.038), and group O was significantly less prevalent (26.2% vs. 30.8%; P = 0.028) in the COVID-19 group than in the control group. Moreover, genotype OO was significantly less common in the COVID-19 group. Furthermore, blood group AB was identified as an independent risk factor for most severe diseases compared with blood group O [aOR (95% CI) = 1.84 (1.00-3.37)]. In ABO genotype analysis, only genotype AB was an independent risk factor for most severe diseases compared with genotype OO. Blood group O is protective, whereas group A is associated with the risk of infection. Moreover, blood group AB is associated with the risk of the "most" severe disease.
Keywords: ABO blood group; ABO genotype; COVID-19; Japanese population.
. 2023 Aug 15.
doi: 10.1007/s00277-023-05407-y. Online ahead of print. Association between ABO blood group/genotype and COVID-19 in a Japanese population
Tatsuya Kusumoto[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 3 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Mayuko Watase[SUP] 4 [/SUP], Kaori Sakurai[SUP] 1 [/SUP], Takanori Asakura[SUP] 1 5 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 6 [/SUP], Naoki Hasegawa[SUP] 7 [/SUP], Norihiro Harada[SUP] 8 [/SUP], Tetsuya Ueda[SUP] 9 [/SUP], Soichiro Ueda[SUP] 10 [/SUP], Takashi Ishiguro[SUP] 11 [/SUP], Ken Arimura[SUP] 12 [/SUP], Fukuki Saito[SUP] 13 [/SUP], Takashi Yoshiyama[SUP] 14 [/SUP], Yasushi Nakano[SUP] 15 [/SUP], Yoshikazu Mutoh[SUP] 16 [/SUP], Yusuke Suzuki[SUP] 5 [/SUP], Ryuya Edahiro[SUP] 17 [/SUP], Hirohito Sano[SUP] 18 [/SUP], Yasunori Sato[SUP] 19 [/SUP], Yukinori Okada[SUP] 20 21 22 23 24 25 [/SUP], Ryuji Koike[SUP] 26 [/SUP], Yuko Kitagawa[SUP] 27 [/SUP], Katsushi Tokunaga[SUP] 28 [/SUP], Akinori Kimura[SUP] 29 [/SUP], Seiya Imoto[SUP] 30 [/SUP], Satoru Miyano[SUP] 31 [/SUP], Seishi Ogawa[SUP] 32 33 34 [/SUP], Takanori Kanai[SUP] 35 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
- PMID: 37581712
- DOI: 10.1007/s00277-023-05407-y
An association between coronavirus disease 2019 (COVID-19) and the ABO blood group has been reported. However, such an association has not been studied in the Japanese population on a large scale. Little is known about the association between COVID-19 and ABO genotype. This study investigated the association between COVID-19 and ABO blood group/genotype in a large Japanese population. All Japanese patients diagnosed with COVID-19 were recruited through the Japan COVID-19 Task Force between February 2020 and October 2021. We conducted a retrospective cohort study involving 1790 Japanese COVID-19 patients whose DNA was used for a genome-wide association study. We compared the ABO blood group/genotype in a healthy population (n = 611, control) and COVID-19 patients and then analyzed their associations and clinical outcomes. Blood group A was significantly more prevalent (41.6% vs. 36.8%; P = 0.038), and group O was significantly less prevalent (26.2% vs. 30.8%; P = 0.028) in the COVID-19 group than in the control group. Moreover, genotype OO was significantly less common in the COVID-19 group. Furthermore, blood group AB was identified as an independent risk factor for most severe diseases compared with blood group O [aOR (95% CI) = 1.84 (1.00-3.37)]. In ABO genotype analysis, only genotype AB was an independent risk factor for most severe diseases compared with genotype OO. Blood group O is protective, whereas group A is associated with the risk of infection. Moreover, blood group AB is associated with the risk of the "most" severe disease.
Keywords: ABO blood group; ABO genotype; COVID-19; Japanese population.