tetano
Editor, Senior Moderator
Ann Hematol
. 2024 Feb 13.
doi: 10.1007/s00277-024-05630-1. Online ahead of print. Coagulation and Inflammation in COVID-19: Reciprocal Relationship between Inflammatory and Coagulation Markers
Rasoul Ebrahimi[SUP] 1 [/SUP], Fatemeh Nasri[SUP] 1 [/SUP], Tahereh Kalantari[SUP] 2 [/SUP]
Affiliations
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as 2019-nCoV. Numerous cellular and biochemical issues arise after COVID-19 infection. The severe inflammation that is caused by a number of cytokines appears to be one of the key hallmarks of COVID-19. Additionally, people with severe COVID-19 have coagulopathy and fulminant thrombotic events. We briefly reviewed the COVID-19 disease at the beginning of this paper. The inflammation and coagulation markers and their alterations in COVID-19 illness are briefly discussed in the parts that follow. Next, we talked about NETosis, which is a crucial relationship between coagulation and inflammation. In the end, we mentioned the two-way relationship between inflammation and coagulation, as well as the factors involved in it. We suggest that inflammation and coagulation are integrated systems in COVID-19 that act on each other in such a way that not only inflammation can activate coagulation but also coagulation can activate inflammation.
Keywords: COVID-19; Coagulation markers; Fibrinolysis system; Inflammation markers; Interleukins; Protein C-protein S system.
. 2024 Feb 13.
doi: 10.1007/s00277-024-05630-1. Online ahead of print. Coagulation and Inflammation in COVID-19: Reciprocal Relationship between Inflammatory and Coagulation Markers
Rasoul Ebrahimi[SUP] 1 [/SUP], Fatemeh Nasri[SUP] 1 [/SUP], Tahereh Kalantari[SUP] 2 [/SUP]
Affiliations
- PMID: 38349409
- DOI: 10.1007/s00277-024-05630-1
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as 2019-nCoV. Numerous cellular and biochemical issues arise after COVID-19 infection. The severe inflammation that is caused by a number of cytokines appears to be one of the key hallmarks of COVID-19. Additionally, people with severe COVID-19 have coagulopathy and fulminant thrombotic events. We briefly reviewed the COVID-19 disease at the beginning of this paper. The inflammation and coagulation markers and their alterations in COVID-19 illness are briefly discussed in the parts that follow. Next, we talked about NETosis, which is a crucial relationship between coagulation and inflammation. In the end, we mentioned the two-way relationship between inflammation and coagulation, as well as the factors involved in it. We suggest that inflammation and coagulation are integrated systems in COVID-19 that act on each other in such a way that not only inflammation can activate coagulation but also coagulation can activate inflammation.
Keywords: COVID-19; Coagulation markers; Fibrinolysis system; Inflammation markers; Interleukins; Protein C-protein S system.