tetano
Editor, Senior Moderator
Ann Hepatol
. 2021 Feb 26;100338.
doi: 10.1016/j.aohep.2021.100338. Online ahead of print.
Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study
Paulina Vidal-Cevallos[SUP] 1 [/SUP], Fatima Higuera-De-La-Tijera[SUP] 2 [/SUP], Norberto C Ch?vez-Tapia[SUP] 3 [/SUP], Francisco Sanchez-Giron[SUP] 4 [/SUP], Eira Cerda Reyes[SUP] 5 [/SUP], Victor Hugo Rosales-Salyano[SUP] 6 [/SUP], Alfredo Servin-Caama?o[SUP] 7 [/SUP], Mart?n Uriel V?zquez Medina[SUP] 8 [/SUP], Nahum Mendez-Sanchez[SUP] 9 [/SUP]
Affiliations
Abstract
Introduction and objectives: As of January 2021, over 88 million people have been infected with COVID-19. Almost two million people have died of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high SOFA score and a D-Dimer >1 ?g/mL identifies patients with high risk of mortality. High lactate dehydrogenase (LDH) levels on admission are associated with severity and mortality. Different degrees of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. The aim of this study was to explore the correlation between LDH and in-hospital mortality in Mexican patients admitted with COVID-19.
Materials & methods: We performed a retrospective multi-centre cohort study with 377 hospitalized patients with confirmed SARS-CoV-2 in three centres in Mexico City, Mexico, who were ≥18 years old and died or were discharged between April 1 and May 31, 2020.
Results: A total of 377 patients were evaluated, 298 (79.1%) patients were discharged, and 79 (20.9%) patients died during hospitalization. Non-survivors were older, with a median age of 46.7 ? 25.7 years old, most patients were male. An ALT > 61 U/l (OR 3.45, 95% CI 1.27-9.37; p = 0.015), C-reactive protein (CRP) > 231 mg/l (OR 4.71, 95% CI 2.35-9.46; p = 0.000), LDH > 561 U/l (OR 3.03, 95% CI 1.40-6.55; p = 0.005) were associated with higher odds for in-hospital death.
Conclusions: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.
Keywords: Severe acute respiratory syndrome coronavirus 2; biochemical markers; mortality determinants; pandemics.; retrospective studies.
. 2021 Feb 26;100338.
doi: 10.1016/j.aohep.2021.100338. Online ahead of print.
Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study
Paulina Vidal-Cevallos[SUP] 1 [/SUP], Fatima Higuera-De-La-Tijera[SUP] 2 [/SUP], Norberto C Ch?vez-Tapia[SUP] 3 [/SUP], Francisco Sanchez-Giron[SUP] 4 [/SUP], Eira Cerda Reyes[SUP] 5 [/SUP], Victor Hugo Rosales-Salyano[SUP] 6 [/SUP], Alfredo Servin-Caama?o[SUP] 7 [/SUP], Mart?n Uriel V?zquez Medina[SUP] 8 [/SUP], Nahum Mendez-Sanchez[SUP] 9 [/SUP]
Affiliations
- PMID: 33647501
- DOI: 10.1016/j.aohep.2021.100338
Abstract
Introduction and objectives: As of January 2021, over 88 million people have been infected with COVID-19. Almost two million people have died of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high SOFA score and a D-Dimer >1 ?g/mL identifies patients with high risk of mortality. High lactate dehydrogenase (LDH) levels on admission are associated with severity and mortality. Different degrees of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. The aim of this study was to explore the correlation between LDH and in-hospital mortality in Mexican patients admitted with COVID-19.
Materials & methods: We performed a retrospective multi-centre cohort study with 377 hospitalized patients with confirmed SARS-CoV-2 in three centres in Mexico City, Mexico, who were ≥18 years old and died or were discharged between April 1 and May 31, 2020.
Results: A total of 377 patients were evaluated, 298 (79.1%) patients were discharged, and 79 (20.9%) patients died during hospitalization. Non-survivors were older, with a median age of 46.7 ? 25.7 years old, most patients were male. An ALT > 61 U/l (OR 3.45, 95% CI 1.27-9.37; p = 0.015), C-reactive protein (CRP) > 231 mg/l (OR 4.71, 95% CI 2.35-9.46; p = 0.000), LDH > 561 U/l (OR 3.03, 95% CI 1.40-6.55; p = 0.005) were associated with higher odds for in-hospital death.
Conclusions: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.
Keywords: Severe acute respiratory syndrome coronavirus 2; biochemical markers; mortality determinants; pandemics.; retrospective studies.