tetano
Editor, Senior Moderator
Ann Hepatol
. 2021 Oct 5;100553.
doi: 10.1016/j.aohep.2021.100553. Online ahead of print.
Liver function as a predictor of mortality in COVID-19. Retrospective study
Fikret Salık[SUP] 1 [/SUP], Osman Uzundere[SUP] 2 [/SUP], Mustafa Bıçak[SUP] 3 [/SUP], Hakan Akelma[SUP] 4 [/SUP], Mesut Akgündüz[SUP] 5 [/SUP], Zeki Korhan[SUP] 6 [/SUP], Deniz Kandemir[SUP] 7 [/SUP], Cem Kıvılcım Kaçar[SUP] 8 [/SUP]
Affiliations
Abstract
Introduction and objectives: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process.
Materials and methods: In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury.
Results: 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected.
Conclusions: The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.
Keywords: Coronavirus disease 2019; critically ill patient; intensive care unit; liver biochemical parameters abnormalities; liver injury; mortality.
. 2021 Oct 5;100553.
doi: 10.1016/j.aohep.2021.100553. Online ahead of print.
Liver function as a predictor of mortality in COVID-19. Retrospective study
Fikret Salık[SUP] 1 [/SUP], Osman Uzundere[SUP] 2 [/SUP], Mustafa Bıçak[SUP] 3 [/SUP], Hakan Akelma[SUP] 4 [/SUP], Mesut Akgündüz[SUP] 5 [/SUP], Zeki Korhan[SUP] 6 [/SUP], Deniz Kandemir[SUP] 7 [/SUP], Cem Kıvılcım Kaçar[SUP] 8 [/SUP]
Affiliations
- PMID: 34624543
- PMCID: PMC8492360
- DOI: 10.1016/j.aohep.2021.100553
Abstract
Introduction and objectives: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process.
Materials and methods: In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury.
Results: 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected.
Conclusions: The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.
Keywords: Coronavirus disease 2019; critically ill patient; intensive care unit; liver biochemical parameters abnormalities; liver injury; mortality.