tetano
Editor, Senior Moderator
Ann Med
. 2024 Dec;56(1):2389301.
doi: 10.1080/07853890.2024.2389301. Epub 2024 Aug 10. Hospitalized children with COVID-19 infection during large outbreak of SARS-CoV-2 Omicron strain: a retrospective study in Chaozhou, Guangdong, China
Fen Lin[SUP] 1 [/SUP], Man-Tong Chen[SUP] 1 [/SUP], Lin Zhang[SUP] 1 [/SUP], He Xie[SUP] 2 [/SUP], Zhe Yang[SUP] 2 [/SUP], Bin Huang[SUP] 2 [/SUP], Jian-Peng Wu[SUP] 2 [/SUP], Wei-Hao Lin[SUP] 2 [/SUP], Li-Ye Yang[SUP] 3 [/SUP]
Affiliations
Objective: We aimed to investigate the clinical findings of hospitalized paediatric COVID-19 patients by the end of 2022.
Method: All confirmed children with COVID-19 infection admitted into Chaozhou Central Hospital during the COVID-19 outbreak from 19 December 2022 to 1 February 2023 were included. Detailed clinical data of those children were evaluated retrospectively.
Results: A total of 286 children, ranging in age from 1 month to 13 years old, were diagnosed with SARS-CoV-2 infection. Among these cases, 138 (48.3%) were categorized as mild, 126 (44.0%) as moderate and 22 (7.7%) as severe/critical. Symptoms varied among the children and included fever, upper respiratory tract symptoms, convulsions, sore throat, poor appetite, dyspnoea and gastrointestinal symptoms. Notably, febrile convulsions were observed in 96 (33.6%) patients, while acute laryngitis was documented in 50 (17.5%) cases. Among the severe/critical patients, eight developed multisystem inflammatory syndrome in children (MIS-C), and tragically, one patient's condition worsened and resulted in death. Furthermore, MRI scans revealed abnormal brain signals in six severe/critical patients. The severe/critical group also exhibited more pronounced laboratory abnormalities, including decreased haemoglobin and elevated ALT, AST, LDH and CK levels.
Conclusions: Febrile convulsions and acute laryngitis are frequently observed in children diagnosed with SARS-CoV-2 Omicron infection. Moreover, MIS-C and abnormal neuroimaging appear to be relatively common phenomena in severe/critical cases.
Keywords: Omicron wave; clinical characteristics; febrile convulsions; multisystem inflammatory syndrome in children (MIS-C); paediatric patients.
. 2024 Dec;56(1):2389301.
doi: 10.1080/07853890.2024.2389301. Epub 2024 Aug 10. Hospitalized children with COVID-19 infection during large outbreak of SARS-CoV-2 Omicron strain: a retrospective study in Chaozhou, Guangdong, China
Fen Lin[SUP] 1 [/SUP], Man-Tong Chen[SUP] 1 [/SUP], Lin Zhang[SUP] 1 [/SUP], He Xie[SUP] 2 [/SUP], Zhe Yang[SUP] 2 [/SUP], Bin Huang[SUP] 2 [/SUP], Jian-Peng Wu[SUP] 2 [/SUP], Wei-Hao Lin[SUP] 2 [/SUP], Li-Ye Yang[SUP] 3 [/SUP]
Affiliations
- PMID: 39126266
- DOI: 10.1080/07853890.2024.2389301
Objective: We aimed to investigate the clinical findings of hospitalized paediatric COVID-19 patients by the end of 2022.
Method: All confirmed children with COVID-19 infection admitted into Chaozhou Central Hospital during the COVID-19 outbreak from 19 December 2022 to 1 February 2023 were included. Detailed clinical data of those children were evaluated retrospectively.
Results: A total of 286 children, ranging in age from 1 month to 13 years old, were diagnosed with SARS-CoV-2 infection. Among these cases, 138 (48.3%) were categorized as mild, 126 (44.0%) as moderate and 22 (7.7%) as severe/critical. Symptoms varied among the children and included fever, upper respiratory tract symptoms, convulsions, sore throat, poor appetite, dyspnoea and gastrointestinal symptoms. Notably, febrile convulsions were observed in 96 (33.6%) patients, while acute laryngitis was documented in 50 (17.5%) cases. Among the severe/critical patients, eight developed multisystem inflammatory syndrome in children (MIS-C), and tragically, one patient's condition worsened and resulted in death. Furthermore, MRI scans revealed abnormal brain signals in six severe/critical patients. The severe/critical group also exhibited more pronounced laboratory abnormalities, including decreased haemoglobin and elevated ALT, AST, LDH and CK levels.
Conclusions: Febrile convulsions and acute laryngitis are frequently observed in children diagnosed with SARS-CoV-2 Omicron infection. Moreover, MIS-C and abnormal neuroimaging appear to be relatively common phenomena in severe/critical cases.
Keywords: Omicron wave; clinical characteristics; febrile convulsions; multisystem inflammatory syndrome in children (MIS-C); paediatric patients.