tetano
Editor, Senior Moderator
Ann Med
. 2020 Nov 13;1-24.
doi: 10.1080/07853890.2020.1851394. Online ahead of print.
Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
Fangzhou Ye[SUP] 1 2 [/SUP], Jing Liu[SUP] 1 2 [/SUP], Liangkai Chen[SUP] 3 [/SUP], Bin Zhu[SUP] 1 2 [/SUP], Li Yu[SUP] 4 [/SUP], Boyun Liang[SUP] 1 2 [/SUP], Ling Xu[SUP] 1 2 [/SUP], Sumeng Li[SUP] 1 2 [/SUP], Sihong Lu[SUP] 1 2 [/SUP], Lei Fan[SUP] 1 2 [/SUP], Dongliang Yang[SUP] 1 2 [/SUP], Xin Zheng[SUP] 1 2 [/SUP]
Affiliations
Abstract
Objective: To illustrate the effect of corticosteroids and heparin, respectively, on Coronavirus Disease 2019 (COVID-19) patients' CD8+ T cells and D-Dimer.
Methods: In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were established to explore the time-course association of representative parameters of coagulation, inflammation and immunity. Segmented regression was performed to examine the influence of corticosteroids and heparin upon CD8+ T cell and D-Dimer, respectively.
Results: There were 541 moderate, 169 severe and 156 critically ill patients involved in the study. Synchronous changes of levels of NLR, D-Dimer and CD8+ T cell in critically ill patients were observed. Administration of methylprednisolone before 14 DFS compared with those after 14 DFS (β = 0.154%, 95% CI=(0, 0.302), p = 0.048) or a dose lower than 40 mg per day compared with those equals to 40 mg per day (β = 0.163%, 95% CI=(0.027, 0.295), p = 0.020) significantly increased the rising rate of CD8+ T cell in 14 to 56 DFS.
Conclusion: The parameters of coagulation, inflammation and immunity were longitudinally correlated, and an early low-dose corticosteroid treatment accelerated the regaining of CD8+ T cell to help battle against SARS-Cov-2 in critical cases of COVID-19.
Keywords: CD8+ T cell; COVID-19; coagulation; corticosteroids; neutrophil to lymphocyte ratio.
. 2020 Nov 13;1-24.
doi: 10.1080/07853890.2020.1851394. Online ahead of print.
Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study
Fangzhou Ye[SUP] 1 2 [/SUP], Jing Liu[SUP] 1 2 [/SUP], Liangkai Chen[SUP] 3 [/SUP], Bin Zhu[SUP] 1 2 [/SUP], Li Yu[SUP] 4 [/SUP], Boyun Liang[SUP] 1 2 [/SUP], Ling Xu[SUP] 1 2 [/SUP], Sumeng Li[SUP] 1 2 [/SUP], Sihong Lu[SUP] 1 2 [/SUP], Lei Fan[SUP] 1 2 [/SUP], Dongliang Yang[SUP] 1 2 [/SUP], Xin Zheng[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33183091
- DOI: 10.1080/07853890.2020.1851394
Abstract
Objective: To illustrate the effect of corticosteroids and heparin, respectively, on Coronavirus Disease 2019 (COVID-19) patients' CD8+ T cells and D-Dimer.
Methods: In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were established to explore the time-course association of representative parameters of coagulation, inflammation and immunity. Segmented regression was performed to examine the influence of corticosteroids and heparin upon CD8+ T cell and D-Dimer, respectively.
Results: There were 541 moderate, 169 severe and 156 critically ill patients involved in the study. Synchronous changes of levels of NLR, D-Dimer and CD8+ T cell in critically ill patients were observed. Administration of methylprednisolone before 14 DFS compared with those after 14 DFS (β = 0.154%, 95% CI=(0, 0.302), p = 0.048) or a dose lower than 40 mg per day compared with those equals to 40 mg per day (β = 0.163%, 95% CI=(0.027, 0.295), p = 0.020) significantly increased the rising rate of CD8+ T cell in 14 to 56 DFS.
Conclusion: The parameters of coagulation, inflammation and immunity were longitudinally correlated, and an early low-dose corticosteroid treatment accelerated the regaining of CD8+ T cell to help battle against SARS-Cov-2 in critical cases of COVID-19.
Keywords: CD8+ T cell; COVID-19; coagulation; corticosteroids; neutrophil to lymphocyte ratio.