tetano
Editor, Senior Moderator
Ann N Y Acad Sci
. 2020 Aug 28.
doi: 10.1111/nyas.14477. Online ahead of print.
Transmission of SARS-CoV-2 through breast milk and breastfeeding: a living systematic review
Elizabeth Centeno-Tablante[SUP] 1 [/SUP], Melisa Medina-Rivera[SUP] 1 [/SUP], Julia L Finkelstein[SUP] 1 [/SUP], Pura Rayco-Solon[SUP] 2 [/SUP], Maria Nieves Garcia-Casal[SUP] 3 [/SUP], Lisa Rogers[SUP] 3 [/SUP], Kate Ghezzi-Kopel[SUP] 4 [/SUP], Pratiwi Ridwan[SUP] 1 [/SUP], Juan Pablo Pe?a-Rosas[SUP] 3 [/SUP], Saurabh Mehta[SUP] 1 [/SUP]
Affiliations
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full-text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID-19 cases based on RT-PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID-19 were positive for SARS-CoV-2 RNA; of the exposed infants, four were positive and two were negative for COVID-19. Currently, there is no evidence of SARS-CoV-2 transmission through breast milk. Studies are needed with longer follow-up periods that collect data on infant feeding practices and on viral presence in breast milk.
Keywords: 2019 nCoV; COVID-19; SARS-CoV-2; breast milk; breastfeeding; mother-to-child transmission; novel coronavirus; perinatal transmission; severe acute respiratory syndrome; vertical transmission.
. 2020 Aug 28.
doi: 10.1111/nyas.14477. Online ahead of print.
Transmission of SARS-CoV-2 through breast milk and breastfeeding: a living systematic review
Elizabeth Centeno-Tablante[SUP] 1 [/SUP], Melisa Medina-Rivera[SUP] 1 [/SUP], Julia L Finkelstein[SUP] 1 [/SUP], Pura Rayco-Solon[SUP] 2 [/SUP], Maria Nieves Garcia-Casal[SUP] 3 [/SUP], Lisa Rogers[SUP] 3 [/SUP], Kate Ghezzi-Kopel[SUP] 4 [/SUP], Pratiwi Ridwan[SUP] 1 [/SUP], Juan Pablo Pe?a-Rosas[SUP] 3 [/SUP], Saurabh Mehta[SUP] 1 [/SUP]
Affiliations
- PMID: 32860259
- DOI: 10.1111/nyas.14477
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full-text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID-19 cases based on RT-PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID-19 were positive for SARS-CoV-2 RNA; of the exposed infants, four were positive and two were negative for COVID-19. Currently, there is no evidence of SARS-CoV-2 transmission through breast milk. Studies are needed with longer follow-up periods that collect data on infant feeding practices and on viral presence in breast milk.
Keywords: 2019 nCoV; COVID-19; SARS-CoV-2; breast milk; breastfeeding; mother-to-child transmission; novel coronavirus; perinatal transmission; severe acute respiratory syndrome; vertical transmission.