tetano
Editor, Senior Moderator
Ann Neurol
. 2022 Feb 11.
doi: 10.1002/ana.26318. Online ahead of print.
COVID-19-associated Critical Illness Myopathy with Direct Viral Effects
Dubravka Dodig[SUP] 1 [/SUP], Mark A Tarnopolsky[SUP] 2 3 [/SUP], Marta Margeta[SUP] 4 [/SUP], Katerina Gordon[SUP] 5 [/SUP], Marvin J Fritzler[SUP] 6 [/SUP], Jian-Qiang Lu[SUP] 5 [/SUP]
Affiliations
Abstract
COVID-19 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined three ICU patients with COVID-19, who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of skeletal muscle biopsies revealed myopathic changes consistent with CIM, variable inflammation with autophagic vacuoles, SARS-CoV immunostaining+ fibers/granules, and electron microscopy findings of mitochondrial abnormalities and coronavirus-like particles. While mitochondrial dysfunction with compromised energy production is a critical pathogenic mechanism of non-COVID-19-associated CIM, in our series of COVID-19-associated CIM, myopathic changes including prominent mitochondrial damage suggest a similar mechanism and association with direct SARS-CoV-2 muscle infection. This article is protected by copyright. All rights reserved.
. 2022 Feb 11.
doi: 10.1002/ana.26318. Online ahead of print.
COVID-19-associated Critical Illness Myopathy with Direct Viral Effects
Dubravka Dodig[SUP] 1 [/SUP], Mark A Tarnopolsky[SUP] 2 3 [/SUP], Marta Margeta[SUP] 4 [/SUP], Katerina Gordon[SUP] 5 [/SUP], Marvin J Fritzler[SUP] 6 [/SUP], Jian-Qiang Lu[SUP] 5 [/SUP]
Affiliations
- PMID: 35148013
- DOI: 10.1002/ana.26318
Abstract
COVID-19 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined three ICU patients with COVID-19, who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of skeletal muscle biopsies revealed myopathic changes consistent with CIM, variable inflammation with autophagic vacuoles, SARS-CoV immunostaining+ fibers/granules, and electron microscopy findings of mitochondrial abnormalities and coronavirus-like particles. While mitochondrial dysfunction with compromised energy production is a critical pathogenic mechanism of non-COVID-19-associated CIM, in our series of COVID-19-associated CIM, myopathic changes including prominent mitochondrial damage suggest a similar mechanism and association with direct SARS-CoV-2 muscle infection. This article is protected by copyright. All rights reserved.