tetano
Editor, Senior Moderator
Ann Clin Transl Neurol. 2019 Nov 12. doi: 10.1002/acn3.50946. [Epub ahead of print] [h=1]Antecedent infections in Guillain-Barr? syndrome: a single-center, prospective study.[/h]
Hao Y[SUP]1[/SUP], Wang W[SUP]1[/SUP], Jacobs BC[SUP]2[/SUP], Qiao B[SUP]1[/SUP], Chen M[SUP]3[/SUP], Liu D[SUP]1[/SUP], Feng X[SUP]1[/SUP], Wang Y[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China. 2 Department of Neurology and Immunology, Erasmus University Medical Centre, Rotterdam, The Netherlands. 3 Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China. 4 Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To investigate the spectrum of antecedent infections in Chinese patients with Guillain-Barr? syndrome (GBS) and analyze the infections-related clinical phenotypes locally.
[h=4]METHODS:[/h] A prospective case-control study of 150 patients diagnosed with GBS and age- and sex-matched neurological and healthy controls was performed to investigate recent infections of 14 pathogens serologically and collect the clinical data during a follow-up of 12 months.
[h=4]RESULTS:[/h] In total, 53% of patients with GBS had a positive serology for recent infection, including Campylobacter jejuni (27%), influenza A (17%) and B (16%), hepatitis A virus (5%), dengue virus (3%), cytomegalovirus (3%), Epstein-Barr virus (3%), Mycoplasma pneumoniae (2%), herpes simplex virus (2%), varicella-zoster virus (1%), and rubella virus (1%). Serology for infections of hepatitis E virus, Haemophilus influenzae, and Zika virus was negative. There was a higher frequency of C. jejuni, influenza A, influenza B, and hepatitis A virus infections in GBS patients than both the neurological and healthy controls. C. jejuni infection was more frequent in younger GBS patients and was associated with antibodies against GM1, GalNAc-GD1a, and GM1:galactocerebroside complex. Influenza B infection was associated with a pure motor form of GBS.
[h=4]INTERPRETATION:[/h] C. jejuni, influenza A, influenza B, and hepatitis A virus serve as the most common cause of antecedent infections in GBS locally. Influenza B-related GBS may represent a pure motor phenotype. Differences in the infectious spectrum worldwide may contribute to the geographical clinical heterogeneity of GBS.
? 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
PMID: 31714025 DOI: 10.1002/acn3.50946
Free full text
Hao Y[SUP]1[/SUP], Wang W[SUP]1[/SUP], Jacobs BC[SUP]2[/SUP], Qiao B[SUP]1[/SUP], Chen M[SUP]3[/SUP], Liu D[SUP]1[/SUP], Feng X[SUP]1[/SUP], Wang Y[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China. 2 Department of Neurology and Immunology, Erasmus University Medical Centre, Rotterdam, The Netherlands. 3 Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China. 4 Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To investigate the spectrum of antecedent infections in Chinese patients with Guillain-Barr? syndrome (GBS) and analyze the infections-related clinical phenotypes locally.
[h=4]METHODS:[/h] A prospective case-control study of 150 patients diagnosed with GBS and age- and sex-matched neurological and healthy controls was performed to investigate recent infections of 14 pathogens serologically and collect the clinical data during a follow-up of 12 months.
[h=4]RESULTS:[/h] In total, 53% of patients with GBS had a positive serology for recent infection, including Campylobacter jejuni (27%), influenza A (17%) and B (16%), hepatitis A virus (5%), dengue virus (3%), cytomegalovirus (3%), Epstein-Barr virus (3%), Mycoplasma pneumoniae (2%), herpes simplex virus (2%), varicella-zoster virus (1%), and rubella virus (1%). Serology for infections of hepatitis E virus, Haemophilus influenzae, and Zika virus was negative. There was a higher frequency of C. jejuni, influenza A, influenza B, and hepatitis A virus infections in GBS patients than both the neurological and healthy controls. C. jejuni infection was more frequent in younger GBS patients and was associated with antibodies against GM1, GalNAc-GD1a, and GM1:galactocerebroside complex. Influenza B infection was associated with a pure motor form of GBS.
[h=4]INTERPRETATION:[/h] C. jejuni, influenza A, influenza B, and hepatitis A virus serve as the most common cause of antecedent infections in GBS locally. Influenza B-related GBS may represent a pure motor phenotype. Differences in the infectious spectrum worldwide may contribute to the geographical clinical heterogeneity of GBS.
? 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
PMID: 31714025 DOI: 10.1002/acn3.50946
Free full text