tetano
Editor, Senior Moderator
Brain Dev. 2014 May 15. pii: S0387-7604(14)00121-1. doi: 10.1016/j.braindev.2014.04.013. [Epub ahead of print]
Anti-aquaporin 4 antibody-positive acute disseminated encephalomyelitis.
Okumura A1, Nakazawa M2, Igarashi A2, Abe S2, Ikeno M2, Nakahara E2, Yamashiro Y3, Shimizu T2, Takahashi T4.
Author information
Abstract
OBJECTIVE:
To describe the clinical and neuroimaging features of a young female patient with acute disseminated encephalomyelitis associated with anti-aquaporin-4 antibodies.
METHODS:
The patient had mild encephalopathy 14days after influenza vaccination. Cerebrospinal fluid analysis revealed an increased cell count and a marked increase in myelin basic protein. Magnetic resonance imaging (MRI) demonstrated multiple lesions in the juxtacortical white matter. The patient was diagnosed with acute disseminated encephalomyelitis and treated with methylprednisolone pulse therapy. She recovered in 1month. However, right retrobulbar optic neuritis appeared 2months after discharge, and serum anti-aquaporin 4 antibodies were measured with a cell-based assay.
RESULTS:
Anti-aquaporin 4 antibodies were present in the patient's serum. She was treated with a prolonged course of oral prednisolone. The patient was negative for serum anti-aquaporin 4 antibodies 8months after the second clinical event, and prednisolone was discontinued 13months after the second clinical event. Serum anti-aquaporin 4 antibodies remained negative 4months after the discontinuation of prednisolone. There was no evidence of relapse at 9months after discontinuation of steroids.
CONCLUSIONS:
This case will expand the spectrum of anti-aquaporin-4 antibody-related central nervous system disorders. The measurement of anti-aquaporin 4 antibody may be considered in patients with a clinical diagnosis of acute disseminated encephalomyelitis and a second clinical event within a short interval.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Acute disseminated encephalomyelitis, Anti-aquaporin 4 antibody, Optic neuritis, Steroids, Vaccination
PMID:
24837901
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24837901
Anti-aquaporin 4 antibody-positive acute disseminated encephalomyelitis.
Okumura A1, Nakazawa M2, Igarashi A2, Abe S2, Ikeno M2, Nakahara E2, Yamashiro Y3, Shimizu T2, Takahashi T4.
Author information
Abstract
OBJECTIVE:
To describe the clinical and neuroimaging features of a young female patient with acute disseminated encephalomyelitis associated with anti-aquaporin-4 antibodies.
METHODS:
The patient had mild encephalopathy 14days after influenza vaccination. Cerebrospinal fluid analysis revealed an increased cell count and a marked increase in myelin basic protein. Magnetic resonance imaging (MRI) demonstrated multiple lesions in the juxtacortical white matter. The patient was diagnosed with acute disseminated encephalomyelitis and treated with methylprednisolone pulse therapy. She recovered in 1month. However, right retrobulbar optic neuritis appeared 2months after discharge, and serum anti-aquaporin 4 antibodies were measured with a cell-based assay.
RESULTS:
Anti-aquaporin 4 antibodies were present in the patient's serum. She was treated with a prolonged course of oral prednisolone. The patient was negative for serum anti-aquaporin 4 antibodies 8months after the second clinical event, and prednisolone was discontinued 13months after the second clinical event. Serum anti-aquaporin 4 antibodies remained negative 4months after the discontinuation of prednisolone. There was no evidence of relapse at 9months after discontinuation of steroids.
CONCLUSIONS:
This case will expand the spectrum of anti-aquaporin-4 antibody-related central nervous system disorders. The measurement of anti-aquaporin 4 antibody may be considered in patients with a clinical diagnosis of acute disseminated encephalomyelitis and a second clinical event within a short interval.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Acute disseminated encephalomyelitis, Anti-aquaporin 4 antibody, Optic neuritis, Steroids, Vaccination
PMID:
24837901
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24837901