tetano
Editor, Senior Moderator
J Agric Food Chem. 2017 Apr 18. doi: 10.1021/acs.jafc.7b00276. [Epub ahead of print]
[h=1]Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action.[/h] Li R, Liu T, Liu M, Chen F, Liu SW, Yang J.
[h=3]Abstract[/h] Dendrobine, a major component of Dendrobium nobile, increasingly draws attention to its wide applications in health care. Here we explore potential effect of dendrobine against influenza A virus and elucidate the underlying mechanism. Our results indicated that dendrobine possessed antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2) with IC50 value of 3.39?0.32, 2.16?0.91, 5.32?1.68 μg/mL, respectively. Mechanism studies revealed that dendrobine inhibited early steps in the viral replication cycle. Notably, dendrobine could bind to the highly conserved region of viral nucleoprotein (NP), subsequently restraining nuclear export of viral NP and its oligomerization. In conclusion, dendrobine shows potential to be developed as a promising agent to treat influenza virus infection. More importantly, the results provide invaluable information for the fully application of Traditional Chinese Medicine named "Shihu".
PMID: 28417634 DOI: 10.1021/acs.jafc.7b00276
[h=1]Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action.[/h] Li R, Liu T, Liu M, Chen F, Liu SW, Yang J.
[h=3]Abstract[/h] Dendrobine, a major component of Dendrobium nobile, increasingly draws attention to its wide applications in health care. Here we explore potential effect of dendrobine against influenza A virus and elucidate the underlying mechanism. Our results indicated that dendrobine possessed antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2) with IC50 value of 3.39?0.32, 2.16?0.91, 5.32?1.68 μg/mL, respectively. Mechanism studies revealed that dendrobine inhibited early steps in the viral replication cycle. Notably, dendrobine could bind to the highly conserved region of viral nucleoprotein (NP), subsequently restraining nuclear export of viral NP and its oligomerization. In conclusion, dendrobine shows potential to be developed as a promising agent to treat influenza virus infection. More importantly, the results provide invaluable information for the fully application of Traditional Chinese Medicine named "Shihu".
PMID: 28417634 DOI: 10.1021/acs.jafc.7b00276