tetano
Editor, Senior Moderator
J Infect Dis. 2016 Dec 15;214(12):1947-1951. Epub 2016 Oct 7.
[h=1]Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.[/h] Petrie JG[SUP]1[/SUP], Parkhouse K[SUP]2,[/SUP][SUP]3[/SUP], Ohmit SE[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], Monto AS[SUP]1[/SUP], Hensley SE[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antigenic drift; correlates of protection; hemagglutinin; household cohort; influenza; influenza vaccine; pandemic H1N1; serum antibody
PMID: 27923954 PMCID: PMC5142093 [Available on 2017-12-15] DOI: 10.1093/infdis/jiw479
[PubMed - in process]
[h=1]Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains.[/h] Petrie JG[SUP]1[/SUP], Parkhouse K[SUP]2,[/SUP][SUP]3[/SUP], Ohmit SE[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], Monto AS[SUP]1[/SUP], Hensley SE[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During the 2013-2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutination-inhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013-2014 season, and we determined whether HAI titers were associated with protection from A(H1N1)pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1)pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] antigenic drift; correlates of protection; hemagglutinin; household cohort; influenza; influenza vaccine; pandemic H1N1; serum antibody
PMID: 27923954 PMCID: PMC5142093 [Available on 2017-12-15] DOI: 10.1093/infdis/jiw479
[PubMed - in process]