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Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines, 25 Se

Biological

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Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines, 25 September 2014

H7N9 (n=454 (at least 171]

Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines, 25 September 2014 [n=454 (at least 171)]

Influenza A(H7N9)
Influenza A(H7) viruses have been detected in poultry populations worldwide with the associated disease ranging from mild to severe. Human infections with avian influenza A(H7N9) viruses were first reported to WHO on 31 March 2013.
Influenza A(H7N9) activity from 18 February 2014 to 23 September 2014
During this period, 99 human cases of avian influenza A(H7N9) virus infection were reported to WHO, bringing the total number of cases to 454 with at least 171 deaths reported
.4

Comparison of avian influenza A(H7N9) viruses isolated from humans, poultry and environmental samples using haemagglutination inhibition assays shows that limited antigenic diversity exists among this group of viruses and the majority remain antigenically similar to the CVV derived from A/Anhui/1/2013-like viruses.
Influenza A(H7N9) candidate vaccine viruses
Based on the current epidemiologic and virologic data, no new A(H7N9) CVVs have been proposed. Available A(H7N9) CVVs are shown in Table 3. National authorities may consider the use of one or more of these A(H7N9) CVVs for pilot lot vaccine production, clinical trials and other pandemic preparedness purposes based on their assessment of public health risk and need. As the viruses continue to evolve, new A(H7N9) CVVs may be developed.
See table
4 Communication from Chinese Center for Disease Control and Prevention (CCDC)

WHO | Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines
http://www.who.int/influenza/vaccines/virus/characteristics_virus_vaccines/en/


Note: 454 ( ? including Beijing?)
 
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