tetano
Editor, Senior Moderator
J Vet Med Sci. 2018 Jun 5. doi: 10.1292/jvms.18-0157. [Epub ahead of print]
[h=1]Antigenic heterogeneity among phylogenetic clusters of influenza D viruses.[/h] Odagiri T[SUP]1[/SUP], Ishida H[SUP]1[/SUP], Li JY[SUP]2[/SUP], Endo M[SUP]2[/SUP], Kobayashi T[SUP]1[/SUP], Kamiki H[SUP]1[/SUP], Matsugo H[SUP]1[/SUP], Takenaka-Uema A[SUP]1[/SUP], Murakami S[SUP]1[/SUP], Horimoto T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutinin-esterase-fusion protein of flu D viruses.
[h=4]KEYWORDS:[/h] antigenicity; cattle; hemagglutinin-esterase-fusion protein; influenza D virus; serology
PMID: 29877211 DOI: 10.1292/jvms.18-0157
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[h=1]Antigenic heterogeneity among phylogenetic clusters of influenza D viruses.[/h] Odagiri T[SUP]1[/SUP], Ishida H[SUP]1[/SUP], Li JY[SUP]2[/SUP], Endo M[SUP]2[/SUP], Kobayashi T[SUP]1[/SUP], Kamiki H[SUP]1[/SUP], Matsugo H[SUP]1[/SUP], Takenaka-Uema A[SUP]1[/SUP], Murakami S[SUP]1[/SUP], Horimoto T[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutinin-esterase-fusion protein of flu D viruses.
[h=4]KEYWORDS:[/h] antigenicity; cattle; hemagglutinin-esterase-fusion protein; influenza D virus; serology
PMID: 29877211 DOI: 10.1292/jvms.18-0157
Free full text