Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Combined Intravenous And Intraventricular Administration Of Colistin Methane Sulphonate In Critically Ill Patients With CNS Infection
Ziaka Mairi 1, Sophia L Markantonis 2, Fousteri Marizoza 2, Zygoulis Paris 1, Dimitris Panidis 2, Karvouniaris Marios 1, Makris Demosthenes 1 and Zakynthinos Epaminondas 1
Author Affiliations: <SUP>1</SUP>Critical Care Department, University Hospital of Larissa, Larissa, Greece <SUP>2</SUP>Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Athens 15771, Greece
ABSTRACT
Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls, n=5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv, n=3) or combined intravenous/intraventricular administration (EVDVcomb, n=4). Cerebrospinal fluid(CSF)/Serum colistin concentration ratios were higher in EVDViv compared to controls (11% vs. 7%, p≤0.05), and in EVDVcomb compared to all other patients (p<0.0001). CSF colistin concentrations >MIC 0.5μg/ml achieved only in EVDVcomb.
FOOTNOTES
Corresponding author: Demosthenes Makris, MD, Department of Critical Care Medicine, University Hospital of Larissa, University of Thessaly School of Medicine, Biopolis, Larisa 41000, Greece. Tel.: +302413502960, email: dimomakris@med.uth.gr; appollon7@hotmail.com; methuth@med.uth.gr
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Ziaka Mairi 1, Sophia L Markantonis 2, Fousteri Marizoza 2, Zygoulis Paris 1, Dimitris Panidis 2, Karvouniaris Marios 1, Makris Demosthenes 1 and Zakynthinos Epaminondas 1
Author Affiliations: <SUP>1</SUP>Critical Care Department, University Hospital of Larissa, Larissa, Greece <SUP>2</SUP>Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Athens 15771, Greece
ABSTRACT
Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls, n=5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv, n=3) or combined intravenous/intraventricular administration (EVDVcomb, n=4). Cerebrospinal fluid(CSF)/Serum colistin concentration ratios were higher in EVDViv compared to controls (11% vs. 7%, p≤0.05), and in EVDVcomb compared to all other patients (p<0.0001). CSF colistin concentrations >MIC 0.5μg/ml achieved only in EVDVcomb.
FOOTNOTES
Corresponding author: Demosthenes Makris, MD, Department of Critical Care Medicine, University Hospital of Larissa, University of Thessaly School of Medicine, Biopolis, Larisa 41000, Greece. Tel.: +302413502960, email: dimomakris@med.uth.gr; appollon7@hotmail.com; methuth@med.uth.gr
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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