Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Comparison of oseltamivir and oseltamivir carboxylate concentrations in venous plasma, venous blood, and capillary blood in healthy volunteers
Insti Instiaty 1,2, Niklas Lindegardh 2,3, Podjanee Jittmala 2, Warunee Hanpithakpong 2, Daniel Blessborn 2,3, Sasithon Pukrittayakamee 1, Nicholas J. White 2,3 and Joel Tarning 2,3,*
Author Affiliations: <SUP>1</SUP>Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand <SUP>2</SUP>Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand <SUP>3</SUP>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
ABSTRACT
Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous blood to plasma ratios were 1.42 (0.920-1.97) for oseltamivir and 0.673 (0.564-0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737-3.16) for oseltamivir and 0.685 (0.502-1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.
FOOTNOTES
* Corresponding author. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand., Phone: +66 22036369, fax: +66 23546018. E-mail: joel@tropmedres.ac
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Insti Instiaty 1,2, Niklas Lindegardh 2,3, Podjanee Jittmala 2, Warunee Hanpithakpong 2, Daniel Blessborn 2,3, Sasithon Pukrittayakamee 1, Nicholas J. White 2,3 and Joel Tarning 2,3,*
Author Affiliations: <SUP>1</SUP>Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand <SUP>2</SUP>Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand <SUP>3</SUP>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
ABSTRACT
Oseltamivir and oseltamivir carboxylate concentrations were measured in venous plasma, venous blood, and capillary blood taken simultaneously from 24 healthy volunteers. Median (range) venous blood to plasma ratios were 1.42 (0.920-1.97) for oseltamivir and 0.673 (0.564-0.814) for oseltamivir carboxylate. Capillary blood/venous plasma ratios were 1.32 (0.737-3.16) for oseltamivir and 0.685 (0.502-1.34) for oseltamivir carboxylate. Oseltamivir concentrations in venous and capillary blood were similar. Oseltamivir carboxylate showed a time-dependent distribution between venous and capillary blood.
FOOTNOTES
* Corresponding author. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand., Phone: +66 22036369, fax: +66 23546018. E-mail: joel@tropmedres.ac
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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