sharon sanders
Editor-in-Chief & President
Phytomedicine. 2020 Jul 17 : 153286.
doi: 10.1016/j.phymed.2020.153286 [Epub ahead of print]
PMCID: PMC7367004
PMID: 32741697Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review
Susmit Mhatre, Tishya Srivastava, Shivraj Naik, and Vandana Patravale[SUP]⁎[/SUP]
Author information Article notes Copyright and License information Disclaimer
Go to:Abstract
Background
The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge.
Purpose
US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
Method
We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
Results
Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3′-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
Conclusion
This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.
Phytomedicine. 2020 Jul 17 : 153286.
doi: 10.1016/j.phymed.2020.153286 [Epub ahead of print]
PMCID: PMC7367004
PMID: 32741697Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review
Susmit Mhatre, Tishya Srivastava, Shivraj Naik, and Vandana Patravale[SUP]⁎[/SUP]
Author information Article notes Copyright and License information Disclaimer
Go to:Abstract
Background
The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge.
Purpose
US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
Method
We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
Results
Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3′-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
Conclusion
This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.
doi: 10.1016/j.phymed.2020.153286 [Epub ahead of print]
PMCID: PMC7367004
PMID: 32741697Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review
Susmit Mhatre, Tishya Srivastava, Shivraj Naik, and Vandana Patravale[SUP]⁎[/SUP]
Author information Article notes Copyright and License information Disclaimer
Go to:Abstract
Background
The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge.
Purpose
US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
Method
We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
Results
Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3′-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
Conclusion
This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.
Phytomedicine. 2020 Jul 17 : 153286.
doi: 10.1016/j.phymed.2020.153286 [Epub ahead of print]
PMCID: PMC7367004
PMID: 32741697Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review
Susmit Mhatre, Tishya Srivastava, Shivraj Naik, and Vandana Patravale[SUP]⁎[/SUP]
Author information Article notes Copyright and License information Disclaimer
Go to:Abstract
Background
The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge.
Purpose
US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
Method
We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
Results
Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3′-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
Conclusion
This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.