tetano
Editor, Senior Moderator
J Leukoc Biol. 2012 Feb 17. [Epub ahead of print]
Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury.
Herold S, Ludwig S, Pleschka S, Wolff T.
Source
*University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany;
Abstract
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
PMID:
22345705
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22345705
Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury.
Herold S, Ludwig S, Pleschka S, Wolff T.
Source
*University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany;
Abstract
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
PMID:
22345705
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22345705