tetano
Editor, Senior Moderator
Transbound Emerg Dis. 2018 Mar 6. doi: 10.1111/tbed.12849. [Epub ahead of print]
[h=1]Appearance of reassortant European avian-origin H1 influenza A viruses of swine in Vietnam.[/h] Takemae N[SUP]1,[/SUP][SUP]2[/SUP], Nguyen PT[SUP]3[/SUP], Le VT[SUP]3[/SUP], Nguyen TN[SUP]4[/SUP], To TL[SUP]5[/SUP], Nguyen TD[SUP]5[/SUP], Pham VP[SUP]3[/SUP], Vo HV[SUP]3[/SUP], Le QVT[SUP]3[/SUP], Do HT[SUP]5[/SUP], Nguyen DT[SUP]4[/SUP], Uchida Y[SUP]1,[/SUP][SUP]2[/SUP], Saito T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Three subtypes-H1N1, H1N2 and H3N2-of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark. In addition, the internal genes of these Vietnamese isolates were derived from human A(H1N1)pdm09 viruses, suggesting that the Vietnamese H1N2 IAVs-S are reassortants between European H1N2 IAVs-S and human A(H1N1)pdm09v. The appearance of European avian-like H1N2 IAVs-S in Vietnam marks their first transmission outside Europe. Our results and statistical analyses of the number of live pigs imported into Vietnam suggest that the European avian-like H1N2 IAVs-S may have been introduced into Vietnam with their hosts through international trade. These findings highlight the importance of quarantining imported pigs to impede the introduction of new IAVs-S.
[h=4]KEYWORDS:[/h] European influenza A virus of swine; Vietnam; influenza A virus; pig
PMID: 29512309 DOI: 10.1111/tbed.12849
[h=1]Appearance of reassortant European avian-origin H1 influenza A viruses of swine in Vietnam.[/h] Takemae N[SUP]1,[/SUP][SUP]2[/SUP], Nguyen PT[SUP]3[/SUP], Le VT[SUP]3[/SUP], Nguyen TN[SUP]4[/SUP], To TL[SUP]5[/SUP], Nguyen TD[SUP]5[/SUP], Pham VP[SUP]3[/SUP], Vo HV[SUP]3[/SUP], Le QVT[SUP]3[/SUP], Do HT[SUP]5[/SUP], Nguyen DT[SUP]4[/SUP], Uchida Y[SUP]1,[/SUP][SUP]2[/SUP], Saito T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Three subtypes-H1N1, H1N2 and H3N2-of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark. In addition, the internal genes of these Vietnamese isolates were derived from human A(H1N1)pdm09 viruses, suggesting that the Vietnamese H1N2 IAVs-S are reassortants between European H1N2 IAVs-S and human A(H1N1)pdm09v. The appearance of European avian-like H1N2 IAVs-S in Vietnam marks their first transmission outside Europe. Our results and statistical analyses of the number of live pigs imported into Vietnam suggest that the European avian-like H1N2 IAVs-S may have been introduced into Vietnam with their hosts through international trade. These findings highlight the importance of quarantining imported pigs to impede the introduction of new IAVs-S.
[h=4]KEYWORDS:[/h] European influenza A virus of swine; Vietnam; influenza A virus; pig
PMID: 29512309 DOI: 10.1111/tbed.12849