tetano
Editor, Senior Moderator
Arch Cardiovasc Dis
. 2020 Aug 17;S1875-2136(20)30157-1.
doi: 10.1016/j.acvd.2020.07.001. Online ahead of print.
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2
Bernard I L?vy[SUP] 1 [/SUP], Jean-Pierre Fauvel[SUP] 2 [/SUP], Soci?t? Fran?aise d’Hypertension Art?rielle
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.
Keywords: Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; Arterial hypertension; Bloqueur des r?cepteurs de l’angiotensine; Heart failure; Hypertension art?rielle; Inhibiteurs de l’enzyme de conversion de l’angiotensine; Insuffisance cardiaque.
. 2020 Aug 17;S1875-2136(20)30157-1.
doi: 10.1016/j.acvd.2020.07.001. Online ahead of print.
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2
Bernard I L?vy[SUP] 1 [/SUP], Jean-Pierre Fauvel[SUP] 2 [/SUP], Soci?t? Fran?aise d’Hypertension Art?rielle
Affiliations
- PMID: 32863157
- DOI: 10.1016/j.acvd.2020.07.001
Abstract
Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.
Keywords: Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; Arterial hypertension; Bloqueur des r?cepteurs de l’angiotensine; Heart failure; Hypertension art?rielle; Inhibiteurs de l’enzyme de conversion de l’angiotensine; Insuffisance cardiaque.