tetano
Editor, Senior Moderator
Arch Endocrinol Metab
. 2021 Jul 16;2359-3997000000384.
doi: 10.20945/2359-3997000000384. Online ahead of print.
Association of diabetes with severity and mortality in hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective study
You-Ping Deng[SUP] #[/SUP][SUP] 1 [/SUP], Wen Xie[SUP] #[/SUP][SUP] 2 [/SUP], Tao Liu[SUP] 3 [/SUP], Shou-Yi Wang[SUP] 1 [/SUP], Yu-Xing Zan[SUP] 4 [/SUP], Mei-Rong Wang[SUP] 4 [/SUP], Xiao-Bo Meng[SUP] 1 [/SUP], Jie Zheng[SUP] 1 [/SUP], Hai-Rong Xiong[SUP] 5 [/SUP], Xue-Dong Fu[SUP] 6 [/SUP]
Affiliations
Abstract
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. The aim this study was to investigate the association of diabetes with severity and mortality among hospitalized patients with COVID-19 in Wuhan, China.
Methods: This retrospective, single-center case study enrolled a total of 564 patients diagnosed with COVID-19 at the Seventh Hospital of Wuhan City, between January 20 and March 15, 2020.
Results: Among the 564 patients with confirmed COVID-19, 509 (85.1%) were discharged and 55 (9.8%) died. The median age was 59 years (range, 10-93 years). A total of 85 (15.1%) patients were diagnosed with diabetes on admission (median age, 65.0 [range, 34-91] years). Patients with diabetes had significantly higher proportions of critical cases (24 [28.2%] vs. 66 [13.8%]) and in-hospital mortality (17 [20%] vs. 38 [7.9%]). Moreover, patients with diabetes presented abnormal levels of multiple indicators concerning lymphopenia, inflammation, heart, liver, kidney, and lung function on admission, while diabetic patient group still display higher troponin T (TnT) levels when approaching discharge. The Kaplan-Meier survival curve indicated a trend toward poorer survival in diabetic patients compared to non-diabetic patients, also evidenced by abnormal laboratory biomarker changes regarding multiple system impairments among COVID-19 patients with diabetes with in-hospital death.
Conclusion: The detailed clinical investigation of 564 hospitalized patients with COVID-19 indicated a considerable association between diabetes and COVID-19 severity or mortality. Thus, more intensive treatment may be considered for COVID-19 patients with diabetes, especially regarding to cardiac injury.
Keywords: COVID-19; clinical characteristics; diabetes; mortality.
. 2021 Jul 16;2359-3997000000384.
doi: 10.20945/2359-3997000000384. Online ahead of print.
Association of diabetes with severity and mortality in hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective study
You-Ping Deng[SUP] #[/SUP][SUP] 1 [/SUP], Wen Xie[SUP] #[/SUP][SUP] 2 [/SUP], Tao Liu[SUP] 3 [/SUP], Shou-Yi Wang[SUP] 1 [/SUP], Yu-Xing Zan[SUP] 4 [/SUP], Mei-Rong Wang[SUP] 4 [/SUP], Xiao-Bo Meng[SUP] 1 [/SUP], Jie Zheng[SUP] 1 [/SUP], Hai-Rong Xiong[SUP] 5 [/SUP], Xue-Dong Fu[SUP] 6 [/SUP]
Affiliations
- PMID: 34283900
- DOI: 10.20945/2359-3997000000384
Abstract
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. The aim this study was to investigate the association of diabetes with severity and mortality among hospitalized patients with COVID-19 in Wuhan, China.
Methods: This retrospective, single-center case study enrolled a total of 564 patients diagnosed with COVID-19 at the Seventh Hospital of Wuhan City, between January 20 and March 15, 2020.
Results: Among the 564 patients with confirmed COVID-19, 509 (85.1%) were discharged and 55 (9.8%) died. The median age was 59 years (range, 10-93 years). A total of 85 (15.1%) patients were diagnosed with diabetes on admission (median age, 65.0 [range, 34-91] years). Patients with diabetes had significantly higher proportions of critical cases (24 [28.2%] vs. 66 [13.8%]) and in-hospital mortality (17 [20%] vs. 38 [7.9%]). Moreover, patients with diabetes presented abnormal levels of multiple indicators concerning lymphopenia, inflammation, heart, liver, kidney, and lung function on admission, while diabetic patient group still display higher troponin T (TnT) levels when approaching discharge. The Kaplan-Meier survival curve indicated a trend toward poorer survival in diabetic patients compared to non-diabetic patients, also evidenced by abnormal laboratory biomarker changes regarding multiple system impairments among COVID-19 patients with diabetes with in-hospital death.
Conclusion: The detailed clinical investigation of 564 hospitalized patients with COVID-19 indicated a considerable association between diabetes and COVID-19 severity or mortality. Thus, more intensive treatment may be considered for COVID-19 patients with diabetes, especially regarding to cardiac injury.
Keywords: COVID-19; clinical characteristics; diabetes; mortality.