tetano
Editor, Senior Moderator
Arch Med Res
. 2020 Aug 7;S0188-4409(20)30681-0.
doi: 10.1016/j.arcmed.2020.07.005. Online ahead of print.
Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis
Luxiang Shang[SUP] 1 [/SUP], Mengjiao Shao[SUP] 2 [/SUP], Qilong Guo[SUP] 3 [/SUP], Jia Shi[SUP] 3 [/SUP], Yang Zhao[SUP] 4 [/SUP], Jiasuoer Xiaokereti[SUP] 3 [/SUP], Baopeng Tang[SUP] 5 [/SUP]
Affiliations
Abstract
Background and aim: Currently, the number of patients with coronavirus disease 2019 (COVID-19) infection is increasing rapidly worldwide. In this study, we aimed to assess whether diabetes mellitus (DM) would increase the risk of severe infection and death in patients with COVID-19.
Methods: We systematically searched the PubMed, Web of Science, MedRxiv and COVID-19 academic research communication platform for studies reporting clinical severity and/or overall mortality data on DM in patients with COVID-19 published up to July 10, 2020. The primary outcome was to compare the severe infection rate and mortality rate in COVID-19 patients with and without DM, and to calculate the odds ratio (OR) and 95% confidence interval (CI).
Results: A total of 76 studies involving 31,067 patients with COVID-19 were included in our meta-analysis. COVID-19 patients with DM had higher severe infection and case-mortality rates compared with those without DM (21.4 vs. 10.6% and 28.5 vs. 13.3%, respectively, all p <0.01). COVID-19 patients with DM were at significantly elevated risk of severe infection (OR = 2.38, 95% CI: 2.05-2.78, p <0.001) and mortality (OR = 2.21, 95% CI: 1.83-2.66, p <0.001).
Conclusion: DM is associated with increased risk of severe infection and higher mortality in patients with COVID-19. Our study suggests that clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with DM.
Keywords: COVID-19; Diabetes mellitus; Disease severity; Meta-analysis; Mortality.
. 2020 Aug 7;S0188-4409(20)30681-0.
doi: 10.1016/j.arcmed.2020.07.005. Online ahead of print.
Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis
Luxiang Shang[SUP] 1 [/SUP], Mengjiao Shao[SUP] 2 [/SUP], Qilong Guo[SUP] 3 [/SUP], Jia Shi[SUP] 3 [/SUP], Yang Zhao[SUP] 4 [/SUP], Jiasuoer Xiaokereti[SUP] 3 [/SUP], Baopeng Tang[SUP] 5 [/SUP]
Affiliations
- PMID: 32811670
- DOI: 10.1016/j.arcmed.2020.07.005
Abstract
Background and aim: Currently, the number of patients with coronavirus disease 2019 (COVID-19) infection is increasing rapidly worldwide. In this study, we aimed to assess whether diabetes mellitus (DM) would increase the risk of severe infection and death in patients with COVID-19.
Methods: We systematically searched the PubMed, Web of Science, MedRxiv and COVID-19 academic research communication platform for studies reporting clinical severity and/or overall mortality data on DM in patients with COVID-19 published up to July 10, 2020. The primary outcome was to compare the severe infection rate and mortality rate in COVID-19 patients with and without DM, and to calculate the odds ratio (OR) and 95% confidence interval (CI).
Results: A total of 76 studies involving 31,067 patients with COVID-19 were included in our meta-analysis. COVID-19 patients with DM had higher severe infection and case-mortality rates compared with those without DM (21.4 vs. 10.6% and 28.5 vs. 13.3%, respectively, all p <0.01). COVID-19 patients with DM were at significantly elevated risk of severe infection (OR = 2.38, 95% CI: 2.05-2.78, p <0.001) and mortality (OR = 2.21, 95% CI: 1.83-2.66, p <0.001).
Conclusion: DM is associated with increased risk of severe infection and higher mortality in patients with COVID-19. Our study suggests that clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with DM.
Keywords: COVID-19; Diabetes mellitus; Disease severity; Meta-analysis; Mortality.