tetano
Editor, Senior Moderator
Arch Physiol Biochem
. 2022 May 26;1-8.
doi: 10.1080/13813455.2022.2080228. Online ahead of print.
High prevalence of SARS-Coronavirus-2 in patients with inflammatory bowel disease and the role of soluble angiotensin converting Enzyme2
Shabnam Shahrokh[SUP] 1 [/SUP], Shaghayegh Baradaran Ghavami[SUP] 1 [/SUP], Hamid Asadzadeh Aghdaei[SUP] 1 [/SUP], Tommaso Lorenzo Parigi[SUP] 2 3 [/SUP], Maryam Farmani[SUP] 1 [/SUP], Silvio Danese[SUP] 2 4 [/SUP], Nasser Ebrahimi Daryani[SUP] 5 [/SUP], Hassan Vossoughinia[SUP] 6 [/SUP], Hedieh Balaii[SUP] 1 [/SUP], Foroogh Alborzi[SUP] 5 [/SUP], Seyed Mobin Khoramjoo[SUP] 1 [/SUP], Binazir Khanabadi[SUP] 1 [/SUP], Ali Seyed Salehi[SUP] 1 [/SUP], Ali Bastani[SUP] 7 [/SUP], Mohsen Sharifi[SUP] 8 [/SUP], Mohammad Taghi Safari[SUP] 1 [/SUP], Habib Malekpour[SUP] 1 [/SUP], Ghazal Sherkat[SUP] 9 [/SUP], Malihe Saberafsharian[SUP] 10 [/SUP], Mohammad Bagher Miri[SUP] 11 [/SUP], Seyed Hamid Moosavi[SUP] 11 [/SUP], Fakhrosadat Anaraki[SUP] 12 [/SUP], Ehsan Nazemalhosseini-Mojarad[SUP] 1 [/SUP], Seyed Reza Mohebi[SUP] 1 [/SUP], Sajad Shojaie[SUP] 1 [/SUP], Mohamad Amin Pourhoseingholi[SUP] 1 [/SUP], Mohammad Reza Zali[SUP] 1 [/SUP]
Affiliations
Abstract
Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection.Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study.Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test.Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups.
Keywords: Inflammatory Bowel disease; SARS-CoV2; sACE.
. 2022 May 26;1-8.
doi: 10.1080/13813455.2022.2080228. Online ahead of print.
High prevalence of SARS-Coronavirus-2 in patients with inflammatory bowel disease and the role of soluble angiotensin converting Enzyme2
Shabnam Shahrokh[SUP] 1 [/SUP], Shaghayegh Baradaran Ghavami[SUP] 1 [/SUP], Hamid Asadzadeh Aghdaei[SUP] 1 [/SUP], Tommaso Lorenzo Parigi[SUP] 2 3 [/SUP], Maryam Farmani[SUP] 1 [/SUP], Silvio Danese[SUP] 2 4 [/SUP], Nasser Ebrahimi Daryani[SUP] 5 [/SUP], Hassan Vossoughinia[SUP] 6 [/SUP], Hedieh Balaii[SUP] 1 [/SUP], Foroogh Alborzi[SUP] 5 [/SUP], Seyed Mobin Khoramjoo[SUP] 1 [/SUP], Binazir Khanabadi[SUP] 1 [/SUP], Ali Seyed Salehi[SUP] 1 [/SUP], Ali Bastani[SUP] 7 [/SUP], Mohsen Sharifi[SUP] 8 [/SUP], Mohammad Taghi Safari[SUP] 1 [/SUP], Habib Malekpour[SUP] 1 [/SUP], Ghazal Sherkat[SUP] 9 [/SUP], Malihe Saberafsharian[SUP] 10 [/SUP], Mohammad Bagher Miri[SUP] 11 [/SUP], Seyed Hamid Moosavi[SUP] 11 [/SUP], Fakhrosadat Anaraki[SUP] 12 [/SUP], Ehsan Nazemalhosseini-Mojarad[SUP] 1 [/SUP], Seyed Reza Mohebi[SUP] 1 [/SUP], Sajad Shojaie[SUP] 1 [/SUP], Mohamad Amin Pourhoseingholi[SUP] 1 [/SUP], Mohammad Reza Zali[SUP] 1 [/SUP]
Affiliations
- PMID: 35617972
- DOI: 10.1080/13813455.2022.2080228
Abstract
Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection.Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study.Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test.Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups.
Keywords: Inflammatory Bowel disease; SARS-CoV2; sACE.
