tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2015 Apr 22:0. [Epub ahead of print]
[h=1]Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study.[/h] Kondo K[SUP]1[/SUP], Suzuki K, Washio M, Ohfuji S, Fukushima W, Maeda A, Hirota Y.
[h=3]Author information[/h]
[h=3]Abstract[/h] We investigated the association between monovalent influenza A (H1N1) pdm09 (H1N1pdm) vaccine and pneumonia in elderly people. Study design was a hospital-based, matched case-control study. Cases comprised patients ≥65 years old who had been newly diagnosed with pneumonia. For each case, two controls were defined as individuals with other diseases (not pneumonia) who were matched by sex, age, entry date, and the visited hospital. Study period was the interval from 1 September 2009 until 30 September 2010. Because a pandemic of influenza A (H1N1) occurred during study period, we analyzed selected subjects who had enrolled during the influenza A (H1N1) pandemic. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for pneumonia in H1N1pdm-vaccinated subjects compared with unvaccinated subjects using a conditional logistic regression model to assess the association between H1N1pdm vaccine and pneumonia. The subjects during the period of the influenza A (H1N1) pandemic were 20 cases and 40 controls. Subjects who had received H1N1pdm vaccine showed a significantly decreased OR for pneumonia (OR = 0.10, 95% CI = 0.01-0.98) compared with unvaccinated subjects. In conclusion, H1N1pdm vaccination may have prevented pneumonia among the elderly during the 2009-2010 influenza A (H1N1) pandemic in Japan.
[h=4]KEYWORDS:[/h] ADL, activities of daily living; CI, confidence interval; COPD, chronic obstructive pulmonary disease; H1N1pdm, monovalent influenza A (H1N1) pdm09; OR, odds ratio; TIV, trivalent seasonal influenza vaccine; effectiveness; elderly people; matched case-control study; monovalent influenza A (H1N1) pdm09 vaccine; pneumonia
PMID: 25901995 [PubMed - as supplied by publisher]
[h=1]Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study.[/h] Kondo K[SUP]1[/SUP], Suzuki K, Washio M, Ohfuji S, Fukushima W, Maeda A, Hirota Y.
[h=3]Author information[/h]
[h=3]Abstract[/h] We investigated the association between monovalent influenza A (H1N1) pdm09 (H1N1pdm) vaccine and pneumonia in elderly people. Study design was a hospital-based, matched case-control study. Cases comprised patients ≥65 years old who had been newly diagnosed with pneumonia. For each case, two controls were defined as individuals with other diseases (not pneumonia) who were matched by sex, age, entry date, and the visited hospital. Study period was the interval from 1 September 2009 until 30 September 2010. Because a pandemic of influenza A (H1N1) occurred during study period, we analyzed selected subjects who had enrolled during the influenza A (H1N1) pandemic. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for pneumonia in H1N1pdm-vaccinated subjects compared with unvaccinated subjects using a conditional logistic regression model to assess the association between H1N1pdm vaccine and pneumonia. The subjects during the period of the influenza A (H1N1) pandemic were 20 cases and 40 controls. Subjects who had received H1N1pdm vaccine showed a significantly decreased OR for pneumonia (OR = 0.10, 95% CI = 0.01-0.98) compared with unvaccinated subjects. In conclusion, H1N1pdm vaccination may have prevented pneumonia among the elderly during the 2009-2010 influenza A (H1N1) pandemic in Japan.
[h=4]KEYWORDS:[/h] ADL, activities of daily living; CI, confidence interval; COPD, chronic obstructive pulmonary disease; H1N1pdm, monovalent influenza A (H1N1) pdm09; OR, odds ratio; TIV, trivalent seasonal influenza vaccine; effectiveness; elderly people; matched case-control study; monovalent influenza A (H1N1) pdm09 vaccine; pneumonia
PMID: 25901995 [PubMed - as supplied by publisher]