tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2019 Oct 7. doi: 10.1080/21645515.2019.1674598. [Epub ahead of print] [h=1]Attitudes, knowledge, and willingness to be vaccinated against seasonal influenza among patients hospitalized with Influenza-Like-Illness: impact of diagnostic testing.[/h]
Tubiana S[SUP]1,[/SUP][SUP]2[/SUP], Launay O[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP], Galtier F[SUP]5,[/SUP][SUP]6[/SUP], Tattevin P[SUP]5,[/SUP][SUP]7[/SUP], Postil D[SUP]5,[/SUP][SUP]8[/SUP], Vanhems P[SUP]5,[/SUP][SUP]9[/SUP], Lanzi N[SUP]5[/SUP], Verger P[SUP]5,[/SUP][SUP]10,[/SUP][SUP]11[/SUP], Duval X[SUP]1,[/SUP][SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Inserm CIC1425 Bichat, H?pital Bichat-Claude Bernard, Assistance Publique-H?pitaux de Paris (AP-HP) , Paris , France. 2 IAME, UMR1137, Sorbonne Paris Cit? , F-75018 Paris , France. 3 Universit? Paris Descartes, Sorbonne Paris Cit?, Inserm , CIC 1417, Paris, France, Paris , France. 4 Assistance Publique-H?pitaux de Paris (AP-HP), H?pital Cochin, CIC Cochin Pasteur Paris , France. 5 Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) , Paris , France. 6 CIC 1411, H?pital Saint-Eloi, CHU de Montpellier , Montpellier , France. 7 H?pital Pontchaillou, INSERM U835, Facult? de M?decine, Universit? Rennes 1 , IFR140 , Rennes. 8 CIC de Limoges, CHU Dupuytren, Limoges , Limoges , France. 9 Service d'Hygi?ne, Epid?miologie et Pr?vention, Groupement Hospitalier Edouard Herriot, Lyon, and Emerging Pathogens Laboratory - Fondation M?rieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111 , CNRS UMR5308, ENS de Lyon, UCBL1, 69007 Lyon , France. 10 UMR VITROME (Vecteurs, Infections TROpicales et MEditerran?ennes), Aix Marseille Univ, INSERM, IRD , Marseille , France. 11 ORS PACA, Observatoire R?gional de la Sant? Provence-Alpes-C?te d׳Azur , Marseille , France.
[h=3]Abstract[/h] Influenza vaccine adherence remains low. Communication of virological diagnosis to adults hospitalized with influenza-like illness (ILI) could improve their willingness to be subsequently vaccinated. We prospectively assessed, in adults hospitalized with ILI in six French university hospitals, their willingness to be vaccinated against influenza in the subsequent season, both before and after the communication of RT-PCR Influenza laboratory result; we identified then the determinants associated with the willingness to be vaccinated. A total of 309 patients were included during the 2012-2013 and 2013-2014 influenza seasons; 43.8% reported being vaccinated against influenza for the current season; before communication of influenza laboratory results, 65.1% reported willingness to be vaccinated during the subsequent season. Influenza was virologically confirmed in 103 patients (33.3%). The rate of vaccine willingness increased to 70.4% (p=0.02) after communication of influenza laboratory results. Factors independently associated with the willingness to be vaccinated were the perception of influenza vaccine benefits (adjusted relative risk (aRR): 1.06, 95%CI 1.02-1.10), cues to action (aRR: 1.08, 95%CI 1.03-1.12), current season influenza vaccination (aRR: 1.38, 95%CI 1.20-1.59) and communication of a positive influenza laboratory result (aRR: 1.18, 95%CI 1.03-1.34). This last was associated with the willingness to be vaccinated only in the subpopulation of patients not vaccinated (aRR: 1.53, 95%CI 1.19-1.96). In patients hospitalized with ILI, communication of a positive influenza diagnostic led to a better appreciation of the disease's severity and increased the willingness to be vaccinated. This approach might be particularly beneficial in patients who do not have a history of influenza vaccination.
[h=4]KEYWORDS:[/h] Influenza; Influenza-like illness; Seasonal influenza vaccine; willingness
PMID: 31589554 DOI: 10.1080/21645515.2019.1674598
Tubiana S[SUP]1,[/SUP][SUP]2[/SUP], Launay O[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP], Galtier F[SUP]5,[/SUP][SUP]6[/SUP], Tattevin P[SUP]5,[/SUP][SUP]7[/SUP], Postil D[SUP]5,[/SUP][SUP]8[/SUP], Vanhems P[SUP]5,[/SUP][SUP]9[/SUP], Lanzi N[SUP]5[/SUP], Verger P[SUP]5,[/SUP][SUP]10,[/SUP][SUP]11[/SUP], Duval X[SUP]1,[/SUP][SUP]2,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h] 1 Inserm CIC1425 Bichat, H?pital Bichat-Claude Bernard, Assistance Publique-H?pitaux de Paris (AP-HP) , Paris , France. 2 IAME, UMR1137, Sorbonne Paris Cit? , F-75018 Paris , France. 3 Universit? Paris Descartes, Sorbonne Paris Cit?, Inserm , CIC 1417, Paris, France, Paris , France. 4 Assistance Publique-H?pitaux de Paris (AP-HP), H?pital Cochin, CIC Cochin Pasteur Paris , France. 5 Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) , Paris , France. 6 CIC 1411, H?pital Saint-Eloi, CHU de Montpellier , Montpellier , France. 7 H?pital Pontchaillou, INSERM U835, Facult? de M?decine, Universit? Rennes 1 , IFR140 , Rennes. 8 CIC de Limoges, CHU Dupuytren, Limoges , Limoges , France. 9 Service d'Hygi?ne, Epid?miologie et Pr?vention, Groupement Hospitalier Edouard Herriot, Lyon, and Emerging Pathogens Laboratory - Fondation M?rieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111 , CNRS UMR5308, ENS de Lyon, UCBL1, 69007 Lyon , France. 10 UMR VITROME (Vecteurs, Infections TROpicales et MEditerran?ennes), Aix Marseille Univ, INSERM, IRD , Marseille , France. 11 ORS PACA, Observatoire R?gional de la Sant? Provence-Alpes-C?te d׳Azur , Marseille , France.
[h=3]Abstract[/h] Influenza vaccine adherence remains low. Communication of virological diagnosis to adults hospitalized with influenza-like illness (ILI) could improve their willingness to be subsequently vaccinated. We prospectively assessed, in adults hospitalized with ILI in six French university hospitals, their willingness to be vaccinated against influenza in the subsequent season, both before and after the communication of RT-PCR Influenza laboratory result; we identified then the determinants associated with the willingness to be vaccinated. A total of 309 patients were included during the 2012-2013 and 2013-2014 influenza seasons; 43.8% reported being vaccinated against influenza for the current season; before communication of influenza laboratory results, 65.1% reported willingness to be vaccinated during the subsequent season. Influenza was virologically confirmed in 103 patients (33.3%). The rate of vaccine willingness increased to 70.4% (p=0.02) after communication of influenza laboratory results. Factors independently associated with the willingness to be vaccinated were the perception of influenza vaccine benefits (adjusted relative risk (aRR): 1.06, 95%CI 1.02-1.10), cues to action (aRR: 1.08, 95%CI 1.03-1.12), current season influenza vaccination (aRR: 1.38, 95%CI 1.20-1.59) and communication of a positive influenza laboratory result (aRR: 1.18, 95%CI 1.03-1.34). This last was associated with the willingness to be vaccinated only in the subpopulation of patients not vaccinated (aRR: 1.53, 95%CI 1.19-1.96). In patients hospitalized with ILI, communication of a positive influenza diagnostic led to a better appreciation of the disease's severity and increased the willingness to be vaccinated. This approach might be particularly beneficial in patients who do not have a history of influenza vaccination.
[h=4]KEYWORDS:[/h] Influenza; Influenza-like illness; Seasonal influenza vaccine; willingness
PMID: 31589554 DOI: 10.1080/21645515.2019.1674598